Evidence map›Paper›PMID 42198959›Full record

ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2026

[Multi-omics integration deciphers immune-metabolic heterogeneity in colorectal cancer: a prognostic model and therapeutic strategies targeting ANGPTL4/FABP4/RBP7].

Ning Ding, Tianshu Peng, Li Mo, Xiangdang Hu, Zongliang Yang, You Xiao, Xiaobing Fu, Jianzheng Zhao, Leilei Li, Yingjie Zhang

Abstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ning DingColorectal Center, Second Affiliated Hospital of Hunan University of Chinese Medicine, Changsha 410005, China.
Tianshu PengColorectal Center, Second Affiliated Hospital of Hunan University of Chinese Medicine, Changsha 410005, China.
Li MoColorectal Center, Second Affiliated Hospital of Hunan University of Chinese Medicine, Changsha 410005, China.
Xiangdang HuColorectal Center, Second Affiliated Hospital of Hunan University of Chinese Medicine, Changsha 410005, China.
Zongliang YangColorectal Center, Second Affiliated Hospital of Hunan University of Chinese Medicine, Changsha 410005, China.
You XiaoColorectal Center, Second Affiliated Hospital of Hunan University of Chinese Medicine, Changsha 410005, China.
Xiaobing FuColorectal Center, Second Affiliated Hospital of Hunan University of Chinese Medicine, Changsha 410005, China.
Jianzheng ZhaoColorectal Center, Second Affiliated Hospital of Hunan University of Chinese Medicine, Changsha 410005, China.
Leilei LiColorectal Center, Second Affiliated Hospital of Hunan University of Chinese Medicine, Changsha 410005, China.
Yingjie ZhangSchool of Biomedical Sciences Hunan University, Changsha 410082, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo explore the heterogeneity of tumor immune microenvironment (TIME) in colorectal cancer (CRC) and the resultant treatment resistance and develop a prognostic model for predicting the treatment outcomes of CRC.

methodsThe multi-omics data including transcriptomic, somatic mutation and single-cell RNA sequencing data of a total of 1136 CRC samples from a TCGA cohort (

resultsThe Immunity_High subtype of CRC was enriched with CD8

conclusionsThe constructed prognostic model and the identified potential therapeutic targets provide new strategies to address immune therapy resistance for CRC.

Indexed as

Angiopoietin-Like Protein 4Colorectal NeoplasmsFatty Acid-Binding ProteinsHumansMultiomicsPrognosisTumor MicroenvironmentAngiopoietin-Like Protein 4ANGPTL4 protein, humanFABP4 protein, humanFatty Acid-Binding ProteinsANGPTL4/FABP4/RBP7colorectal cancerimmune-metabolic heterogeneitymulti-omics integrationprognostic model

Identifiers

PMID42198959
PMCPMC13213725

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.