ArticleYonsei medical journal2026
Bone Bridge Effect for the Treatment of Acute Osteoporotic Vertebral Compression Fractures: A Multistrategic Approach Using an Anabolic Agent.
Article in Yonsei medical journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo determine the bone bridge effect (BBE) and compare treatment outcomes of different osteoporosis medications in patients with lumbar osteoporotic vertebral compression fractures (OVCF). MATERIALS AND
methodsThis study followed 264 patients with lumbar OVCFs undergoing conservative treatment for more than 12 months. Patients were divided into four groups based on medication: denosumab monotherapy (group D), teriparatide and denosumab combination (group TDco), sequential romosozumab followed by denosumab (group RDse), and bisphosphonate monotherapy (group B). Changes in bone mineral density (BMD), radiological parameters including BBE, and visual analog scale (VAS) scores were compared from injury to 1 year post-injury.
resultsThe 1-year BBE incidence was highest in groups treated with anabolic agents: group RDse (56.3%) and group TDco (51.8%). These rates were significantly higher than in group D (28.6%) and group B (21.1%). The annual BMD increase was significantly greater in group TDco (1.04) compared to the other groups (RDse: 0.63; D: 0.55; B: 0.35). VAS scores decreased significantly by the 3-month mark in anabolic agent groups and in patients with confirmed BBE, indicating rapid pain relief. Multivariate logistic regression analysis confirmed that anabolic agent groups (TDco and RDse) were significant independent predictors of BBE formation (odds ratio 2.717 and 3.472, respectively), even after adjusting for confounding variables such as initial BMD.
conclusionAnabolic agents appeared to be associated with more BBE formation, greater BMD gains, and faster pain reduction compared to anti-resorptive agents. Therefore, treatment strategies using anabolic agents, such as those in groups TDco and RDse, may be important considerations for treating patients with OVCFs.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.