Genetic Characterization of Yellow Fever Virus Strain JSS, the Original South American Strain.

Madison E Lee, Clairissa A Hansen, Jill K Thompson, Haiping Hao, Nigel Bourne, Alan D T Barrett

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Article in Viruses, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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5 · Who and what money

Authors and funding

6 authors.

Madison E LeeDepartment of Pathology, University of Texas Medical Branch (UTMB), Galveston, TX 77555, USA.

Clairissa A HansenDepartment of Pathology, University of Texas Medical Branch (UTMB), Galveston, TX 77555, USA.ORCID 0000-0002-4841-2456

Jill K ThompsonDepartment of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555, USA.ORCID 0009-0007-5354-4393

Haiping HaoDepartment of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555, USA.ORCID 0000-0002-8826-1568

Nigel BourneSealy Institute for Vaccine Sciences, University of Texas Medical Branch, Galveston, TX 77555, USA.

Alan D T BarrettDepartment of Pathology, University of Texas Medical Branch (UTMB), Galveston, TX 77555, USA.ORCID 0000-0003-3740-7448

Funding

National Institute of Allergy and Infectious Diseases R21 AI 156059

6 · The paper itself

Abstract

Yellow fever virus (YFV) is divided into seven genotypes, including West Africa II (WAII) and South America I (SAI). The first wild-type YFVs isolated, Asibi (Ghana/1927) and French Viscerotropic virus ([FVV] Senegal/1927), are members of WAII. The first YFV strain isolated in South America, JSS (Brazil/1935), was associated with the last outbreak of urban YF in Brazil and has been insufficiently studied. We utilized Next Generation Sequencing to compare JSS with Asibi, FVV, and other South American YFV strains. SAI strains, including JSS, had higher genetic diversity than WAII strains. Phylogenetic and phylogeographic studies of YFV in South America have revealed the circulation of five lineages within Brazil, termed 1A-1E. JSS was found to be distinct from the five genetic lineages currently recognized in Brazil, and so we termed JSS as the currently sole member of Brazilian linage 1F. a comparison of JSS with all other Brazilian genomes of YFV suggests that lineage 1F appears to have become extinct.

Indexed as

Genetic VariationYellow FeverYellow fever virusAnimalsBrazilGenome, ViralGenotypeHigh-Throughput Nucleotide SequencingHumansPhylogenyPhylogeographySequence Analysis, DNASouth AmericaBrazilian yellow fever virusJSSSouth Americayellow fever virus

Identifiers

PMID42198767

DOI10.3390/v18050564

PMCPMC13211568

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.