ArticleViruses2026
Sphingosine-1-Phosphate Receptor and Kinase Expression in the Reproductive Tract Is Associated with HIV Infection and Preterm Birth in a Cohort of Pregnant Women in Zambia.
Rachel S Resop, Innocent Mwape, Yuri V Sebastião, Katelyn J Rittenhouse, Ntazana Sindano, Humphrey Mwape, Margaret P Kasaro, Bellington Vwalika, Joan T Price, Jeffrey S A Stringer and 1 more
Abstract read
In one paragraphArticle in Viruses, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
11 authors.
Rachel S ResopDepartment of Obstetrics and Gynecology, School of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA.ORCID 0000-0003-3833-2433 Innocent MwapeCentre for Infectious Disease Research, Lusaka 10101, Zambia.
Yuri V SebastiãoDepartment of Obstetrics and Gynecology, School of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA.ORCID 0000-0002-4268-3095 Katelyn J RittenhouseDepartment of Obstetrics and Gynecology, School of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA.ORCID 0000-0002-5571-0793 Ntazana SindanoUNC Global Projects-Zambia, LLC, Lusaka 10101, Zambia.
Humphrey MwapeUNC Global Projects-Zambia, LLC, Lusaka 10101, Zambia.
Margaret P KasaroUNC Global Projects-Zambia, LLC, Lusaka 10101, Zambia.
Bellington VwalikaObstetrics and Gynaecology, School of Medicine, University of Zambia, Lusaka 10101, Zambia.
Joan T PriceDepartment of Obstetrics and Gynecology, School of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA.
Jeffrey S A StringerDepartment of Obstetrics and Gynecology, School of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA.
Kristina De ParisDepartment of Microbiology and Immunology, School of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA.ORCID 0000-0001-5199-3004 Funding
UNC Global Women’s Health FellowshipT32HD075731 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI CHI, BENJAMIN H. · 2013 to 2024
$2.4MA Career Development Award in AI-Assisted Ultrasound for Early Pregnancy LocalizationK23HD118285 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Katelyn Joy Rittenhouse · 2025 to 2026
$360kNICHD NIH HHS K23 HD118285NICHD NIH HHS L30 HD119794NIH, Fogarty International Center, Global Health Research Fellowship T32HD075731
6 · The paper itselfAbstract
Women living with HIV face an increased burden of spontaneous preterm birth (sPTB); however, the underlying immunological mechanisms of sPTB and its association with HIV infection are poorly understood. Although the limited earlier literature implicates sphingosine-1-phosphate (S1P), a lysosphingolipid signaling molecule, in reproductive biology, the association of S1P signaling with HIV and sPTB has not been investigated. We examined whether two S1P signaling components, S1P receptors and sphingosine kinases, are expressed in the female reproductive tract and whether levels are associated with HIV status or spontaneous preterm birth. We quantified the mRNA expression of sphingosine-1-phosphate receptors 1 and 3 (
Indexed as
Genitalia, FemaleHIV InfectionsPhosphotransferases (Alcohol Group Acceptor)Pregnancy Complications, InfectiousPremature BirthSphingosine-1-Phosphate ReceptorsAdultCohort StudiesFemaleHumansPregnancySphingosine KinaseYoung AdultZambiaPhosphotransferases (Alcohol Group Acceptor)Sphingosine-1-Phosphate ReceptorsSphingosine Kinaseadverse birth outcomesfemale reproductive tracthuman immunodeficiency viruslongitudinal pregnancy cohortpreterm birthsphingosine-1-phosphate
Identifiers
PMID42198762
PMCPMC13211646
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