Evidence map›Paper›PMID 42198753›Full record

ArticleViruses2026

Microglial-Derived IGF-1 Serves as a Regulator for Neuroimmune Homeostasis During Viral-Induced Demyelination.

Vanessa M Scarfone, Collin Pachow, Pauline U Nguyen, Anita Lakatos, Jamie-Jean De La Torre, Alisa Xie, Kellie Fernandez, Charlene Collado, Kaitlin Murray, Roberto Tinoco and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Vanessa M ScarfoneSue & Bill Gross Stem Cell Research Center, University of California, Irvine, CA 92697, USA.ORCID 0000-0001-8786-4191
Collin PachowDepartment of Molecular Biology and Biochemistry, School of Biological Sciences, University of California, Irvine, CA 92697, USA.ORCID 0009-0007-7776-848X
Pauline U NguyenSue & Bill Gross Stem Cell Research Center, University of California, Irvine, CA 92697, USA.
Anita LakatosSue & Bill Gross Stem Cell Research Center, University of California, Irvine, CA 92697, USA.
Jamie-Jean De La TorreDepartment of Molecular Biology and Biochemistry, School of Biological Sciences, University of California, Irvine, CA 92697, USA.ORCID 0000-0002-4829-7021
Alisa XieDepartment of Neurobiology and Behavior, University of California, Irvine, 2213 McGaugh Hall, Irvine, CA 92697, USA.
Kellie FernandezDepartment of Neurobiology and Behavior, University of California, Irvine, 2213 McGaugh Hall, Irvine, CA 92697, USA.
Charlene ColladoDepartment of Neurobiology and Behavior, University of California, Irvine, 2213 McGaugh Hall, Irvine, CA 92697, USA.
Kaitlin MurrayDepartment of Neurobiology and Behavior, University of California, Irvine, 2213 McGaugh Hall, Irvine, CA 92697, USA.
Roberto TinocoDepartment of Molecular Biology and Biochemistry, School of Biological Sciences, University of California, Irvine, CA 92697, USA.
Craig M WalshSue & Bill Gross Stem Cell Research Center, University of California, Irvine, CA 92697, USA.ORCID 0000-0001-7808-2817
Trevor OwensNeurobiology Research, Department of Molecular Medicine, University of Southern Denmark, 5000 Odense, Denmark.ORCID 0000-0001-9315-6036
Agnieszka WlodarczykNeurobiology Research, Department of Molecular Medicine, University of Southern Denmark, 5000 Odense, Denmark.ORCID 0000-0003-4123-368X
Thomas E LaneDepartment of Molecular Biology and Biochemistry, School of Biological Sciences, University of California, Irvine, CA 92697, USA.ORCID 0000-0003-0392-0825

Funding

Univ.of Calif., Irvine Cancer Center Support GrantP30CA062203 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Melanie Funes · 1994 to 2026
$57.9M
NCI NIH HHS P30 CA062203
6 · The paper itself

Abstract

This study investigated the role of microglia-derived insulin-like growth factor 1 (IGF-1) in modulating host defense and disease progression in a viral model of neuroinflammation and demyelination. Intracranial infection of susceptible mice with the glial-tropic JHM strain of mouse hepatitis virus (JHMV) induces acute encephalomyelitis, followed by an immune-mediated demyelinating disease that mimics many clinical and histologic features of multiple sclerosis (MS). Utilizing an inducible fractalkine receptor (

Indexed as

Demyelinating DiseasesHomeostasisInsulin-Like Growth Factor IMicrogliaNeuroimmunomodulationAnimalsDisease Models, AnimalEncephalomyelitisMiceMurine hepatitis virusSpinal Cordinsulin-like growth factor-1, mouseInsulin-Like Growth Factor Icoronavirusesdemyelinationneuroinflammationneurovirology

Identifiers

PMID42198753
PMCPMC13211618

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.