Evidence map›Paper›PMID 42198675›Full record

ArticlePathogens (Basel, Switzerland)2026

Prevalence of Hepatitis E Virus Infection Among Pregnant Women in Tunisia: Findings from a Large Cohort Study.

Kaouther Ayouni, Mariem Gdoura, Rania Allègue, Majdi Ben Ameur, Henda Touzi, Nesrine Abderahmane, Khaoula Magdoud, Hiba Mkadmi, Rim Ben Hmid, Henda Triki and 1 more

Abstract read
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In one paragraph

Article in Pathogens (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Kaouther AyouniLaboratory of Clinical Virology, WHO Reference Laboratory for Poliomyelitis and Measles in the Eastern Mediterranean Region, Pasteur Institute of Tunis, University of Tunis El Manar, 13 Place Pasteur, BP 74, Tunis 1002, Tunisia.ORCID 0000-0002-0872-5706
Mariem GdouraLaboratory of Clinical Virology, WHO Reference Laboratory for Poliomyelitis and Measles in the Eastern Mediterranean Region, Pasteur Institute of Tunis, University of Tunis El Manar, 13 Place Pasteur, BP 74, Tunis 1002, Tunisia.ORCID 0000-0002-2031-6534
Rania AllègueLaboratory of Clinical Virology, WHO Reference Laboratory for Poliomyelitis and Measles in the Eastern Mediterranean Region, Pasteur Institute of Tunis, University of Tunis El Manar, 13 Place Pasteur, BP 74, Tunis 1002, Tunisia.
Majdi Ben AmeurLaboratory of Clinical Virology, WHO Reference Laboratory for Poliomyelitis and Measles in the Eastern Mediterranean Region, Pasteur Institute of Tunis, University of Tunis El Manar, 13 Place Pasteur, BP 74, Tunis 1002, Tunisia.
Henda TouziLaboratory of Clinical Virology, WHO Reference Laboratory for Poliomyelitis and Measles in the Eastern Mediterranean Region, Pasteur Institute of Tunis, University of Tunis El Manar, 13 Place Pasteur, BP 74, Tunis 1002, Tunisia.
Nesrine AbderahmaneLaboratory of Clinical Virology, WHO Reference Laboratory for Poliomyelitis and Measles in the Eastern Mediterranean Region, Pasteur Institute of Tunis, University of Tunis El Manar, 13 Place Pasteur, BP 74, Tunis 1002, Tunisia.
Khaoula MagdoudDepartment of Gynecology Emergency, Center of Maternity and Neonatology, Boulevard 9 Avril, Tunis 1006, Tunisia.
Hiba MkadmiDepartment of Gynecology Emergency, Center of Maternity and Neonatology, Boulevard 9 Avril, Tunis 1006, Tunisia.ORCID 0009-0001-4175-8227
Rim Ben HmidDepartment of Gynecology Emergency, Center of Maternity and Neonatology, Boulevard 9 Avril, Tunis 1006, Tunisia.
Henda TrikiLaboratory of Clinical Virology, WHO Reference Laboratory for Poliomyelitis and Measles in the Eastern Mediterranean Region, Pasteur Institute of Tunis, University of Tunis El Manar, 13 Place Pasteur, BP 74, Tunis 1002, Tunisia.
Anissa ChouikhaLaboratory of Clinical Virology, WHO Reference Laboratory for Poliomyelitis and Measles in the Eastern Mediterranean Region, Pasteur Institute of Tunis, University of Tunis El Manar, 13 Place Pasteur, BP 74, Tunis 1002, Tunisia.ORCID 0000-0001-5616-0204

Funding

Gates Foundation INV-050512
6 · The paper itself

Abstract

Hepatitis E is a liver inflammation caused by the hepatitis E virus (HEV). In pregnant women, the infection significantly increases the risk of acute liver failure, fetal loss, and maternal death. According to the World Health Organization, infection by HEV during the third trimester of pregnancy may increase the risk of maternal mortality in 20-25% of cases. In Tunisia, little is known about HEV infection and its outcome, especially in pregnant women. This study aims to evaluate the prevalence of HEV infection in a large cohort of pregnant women in Tunisia. A total of 891 women who attended the Centre of Maternity and Neonatology of Tunis during 2021-2023 were included. Serum samples were screened to detect HEV-antibodies and RNA using commercial ELISA tests and molecular assays, respectively. Statistical analyses were conducted using SPSS 21.0 software and the EPISTAT package version 7.2.6. Seroprevalence of HEV infection was 3.82%, based on the detection of anti-HEV IgG. The distribution of the seroprevalence according to age was statistically significant (

Indexed as

Hepatitis EHepatitis E virusPregnancy Complications, InfectiousAdultCohort StudiesEnzyme-Linked Immunosorbent AssayFemaleHepatitis AntibodiesHumansImmunoglobulin GPregnancyPrevalenceRNA, ViralSeroepidemiologic StudiesTunisiaYoung AdultHepatitis AntibodiesImmunoglobulin GRNA, Viralhepatitis E infectionhepatitis E viruspregnancyprevalenceserologyTunisia

Identifiers

PMID42198675
PMCPMC13209197

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.