Evidence map›Paper›PMID 42198663›Full record

ArticlePathogens (Basel, Switzerland)2026

Koilocytosis in LSIL Cytology Has Limited Predictive Value for CIN2+ in HPV-Positive Women: Implications for Risk-Based Cytology Triage.

Yukimi Misawa, Shuichi Mizuno, Saeka Honda, Ruku Shinohara, Koki Kikuchi, Rei Settsu, Kaori Okayama, Masahiko Fujii, Mizue Oda, Mitsuaki Okodo

Abstract read
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In one paragraph

Article in Pathogens (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yukimi MisawaDepartment of Medical Technology, Faculty of Health Sciences, Kyorin University, 5-4-1 Shimorenjaku, Mitaka-shi 181-8621, Japan.
Shuichi MizunoDepartment of Medical Technology, Faculty of Health Sciences, Kyorin University, 5-4-1 Shimorenjaku, Mitaka-shi 181-8621, Japan.
Saeka HondaDepartment of Medical Technology, Faculty of Health Sciences, Kyorin University, 5-4-1 Shimorenjaku, Mitaka-shi 181-8621, Japan.
Ruku ShinoharaDepartment of Medical Technology, Faculty of Health Sciences, Kyorin University, 5-4-1 Shimorenjaku, Mitaka-shi 181-8621, Japan.
Koki KikuchiDepartment of Medical Technology, Faculty of Health Sciences, Kyorin University, 5-4-1 Shimorenjaku, Mitaka-shi 181-8621, Japan.
Rei SettsuDepartment of Medical Technology, Faculty of Health Sciences, Kyorin University, 5-4-1 Shimorenjaku, Mitaka-shi 181-8621, Japan.
Kaori OkayamaSchool of Health Sciences, Department of Medical Technology and Sciences, International University of Health and Welfare, 2600-1 Kitakanemaru, Otawara-shi 324-8501, Japan.ORCID 0000-0002-5994-9670
Masahiko FujiiDepartment of Clinical Laboratory, Genki Plaza Medical Center for Health Care, 1-7-1 Jinbocho, Chiyoda-ku, Tokyo 101-0051, Japan.
Mizue OdaDepartment of Gynecology, Genki Plaza Medical Center for Health Care, 1-105 Jinbocho, Chiyoda-ku, Tokyo 101-0051, Japan.
Mitsuaki OkodoDepartment of Medical Technology, Faculty of Health Sciences, Kyorin University, 5-4-1 Shimorenjaku, Mitaka-shi 181-8621, Japan.ORCID 0000-0001-6152-3217

Funding

Japan Society for the Promotion of Science 26K13221
6 · The paper itself

Abstract

Cervical cancer screening with high-risk human papillomavirus (HR-HPV) testing requires effective triage of HPV-positive women. Koilocytosis is a classic cytopathic effect of HPV infection, but its clinical significance in low-grade squamous intraepithelial lesions (LSILs) remains unclear. We retrospectively evaluated 157 HPV-positive women with LSIL cytology and follow-up data, including 140 women with concurrent biopsy results. Koilocytes were identified in 93/157 cases (59.2%) and were less frequent in HPV16/18-positive cases. Cervical intraepithelial neoplasia ≥ grade 2 (CIN2+) was detected in 9/84 koilocyte-positive cases (10.7%) and 16/56 koilocyte-negative cases (28.6%), whereas non-CIN findings were more common in koilocyte-positive cases. Koilocyte-positive cases also showed a longer time to regression from LSIL to negative for intraepithelial lesions or malignancy. These findings suggest that koilocytosis mainly reflects productive HPV infection and has limited utility for predicting CIN2+ in HPV-based screening triage. Excluding koilocytosis-driven low-grade cytological changes from triage positivity criteria may improve specificity and positive predictive value, supporting higher triage thresholds.

Indexed as

Papillomavirus InfectionsSquamous Intraepithelial Lesions of the CervixUterine Cervical DysplasiaUterine Cervical NeoplasmsAdultCytodiagnosisEarly Detection of CancerFemaleHumansMiddle AgedPapillomaviridaePredictive Value of TestsRetrospective StudiesTriagecervical cancer screeningCIN2+cytologycytology triageHPV genotypinghuman papillomaviruskoilocytosisLSILproductive HPV infectionrisk stratification

Identifiers

PMID42198663
PMCPMC13209615

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.