ArticlePathogens (Basel, Switzerland)2026
Vitamin A Modulates AHR Signaling and Restricts Zika Virus Replication in Human Retinal Pigment Epithelial Cells: Insights from Molecular Modeling and Antiviral Assays.
Agostina B Marquez, Priscila A Lanza Castronuovo, Cecilia L Barbieri, Mayra A Castañeda Cataña, Claudia S Sepúlveda, Agustina Alaimo, D Mariano A Vera, Cybele C García
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In one paragraphArticle in Pathogens (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
8 authors.
Agostina B MarquezLaboratorio de Estrategias Antivirales, Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires (UBA), Intendente Güiraldes 2160, Ciudad Autónoma de Buenos Aires 1428, Argentina.
Priscila A Lanza CastronuovoQUIAMM-INBIOTEC, Departamento de Química y Bioquímica, Facultad de Ciencias Exactas y Naturales, Universidad Nacional de Mar del Plata, Funes 3350, Mar del Plata 7600, Argentina.ORCID 0000-0002-5872-5237 Cecilia L BarbieriQUIAMM-INBIOTEC, Departamento de Química y Bioquímica, Facultad de Ciencias Exactas y Naturales, Universidad Nacional de Mar del Plata, Funes 3350, Mar del Plata 7600, Argentina.
Mayra A Castañeda CatañaLaboratorio de Estrategias Antivirales, Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires (UBA), Intendente Güiraldes 2160, Ciudad Autónoma de Buenos Aires 1428, Argentina.
Claudia S SepúlvedaLaboratorio de Estrategias Antivirales, Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires (UBA), Intendente Güiraldes 2160, Ciudad Autónoma de Buenos Aires 1428, Argentina.ORCID 0000-0003-2356-6624 Agustina AlaimoInstituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales (IQUIBICEN), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET)-UBA, Intendente Güiraldes 2160, Ciudad Autónoma de Buenos Aires 1428, Argentina.ORCID 0000-0002-8070-9620 D Mariano A VeraQUIAMM-INBIOTEC, Departamento de Química y Bioquímica, Facultad de Ciencias Exactas y Naturales, Universidad Nacional de Mar del Plata, Funes 3350, Mar del Plata 7600, Argentina.
Cybele C GarcíaLaboratorio de Estrategias Antivirales, Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires (UBA), Intendente Güiraldes 2160, Ciudad Autónoma de Buenos Aires 1428, Argentina.ORCID 0000-0002-6431-7176 Funding
Agencia Nacional de Promoción de la Investigación, el Desarrollo Tecnológico y la Innovación PICT 2021-1306 and PICT-2023-2027-I-A-00940Ministry of Science, Technology and Innovation Clementina XXI, IPAC PCI_123National Scientific and Technical Research Council PIP11220170100171COUniversity of Buenos Aires 20020190100013BA
6 · The paper itselfAbstract
Zika virus (ZIKV) is an emerging flavivirus associated with congenital malformations and ocular complications, representing a significant public health concern. Retinal pigment epithelium (RPE) cells play a key role in maintaining retinal integrity and represent a primary target of ZIKV infection, making them a relevant model for studying host-virus interactions. In this study, we evaluated the antiviral activity of fat- and water-soluble vitamins against ZIKV in hTERT RPE-1 (hRPE1) cells. Particularly, vitamin A was identified as the compound that most effectively inhibited viral replication. Molecular dynamics simulations focusing on the PAS-B domain of the aryl hydrocarbon receptor (AHR) revealed a high affinity of vitamin A for the receptor. In hRPE1 cells, vitamin A treatment reduced viral RNA levels and decreased
Indexed as
Antiviral AgentsReceptors, Aryl HydrocarbonRetinal Pigment EpitheliumSignal TransductionVirus ReplicationVitamin AZika VirusZika Virus InfectionAnimalsCell LineChlorocebus aethiopsEpithelial CellsHost-Pathogen InteractionsHumansMolecular Dynamics SimulationVero CellsAntiviral AgentsReceptors, Aryl HydrocarbonVitamin Aantiviral combination therapyaryl hydrocarbon receptor (AHR)host-directed antiviral therapymolecular dynamics simulationsresveratrolretinal pigment epithelium (RPE)vitamin Azika virus (ZIKV)
Identifiers
PMID42198644
PMCPMC13209694
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