ArticlePathogens (Basel, Switzerland)2026
Genetic Characterization of First-Line Drug-Resistance Mutations in Multidrug-Resistant
Maryam Gul, Sajid Ali, Abdul Rehman, Muhammad Qasim, Roomana Ali, Jody E Phelan, Aiman Waheed, Sajjad Ahmad, Mubbashir Hussain, Susana Campino and 2 more
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In one paragraphArticle in Pathogens (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
12 authors.
Maryam GulDepartment of Microbiology, Kohat University of Science and Technology, Kohat 26000, Khyber Pakhtunkhwa, Pakistan.
Sajid AliInstitute of Biotechnology and Microbiology, Bacha Khan University, Charsadda 24420, Khyber Pakhtunkhwa, Pakistan.ORCID 0000-0002-3654-6529 Abdul RehmanDepartment of Microbiology, Kohat University of Science and Technology, Kohat 26000, Khyber Pakhtunkhwa, Pakistan.ORCID 0000-0001-9004-6384 Muhammad QasimDepartment of Microbiology, Kohat University of Science and Technology, Kohat 26000, Khyber Pakhtunkhwa, Pakistan.
Roomana AliAtta ur Rahman School of Applied Biosciences (ASAB), National University of Sciences and Technology (NUST), Islamabad 44000, Islamabad, Pakistan.ORCID 0000-0002-2919-0659 Jody E PhelanFaculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK.
Aiman WaheedCenter of Biotechnology and Microbiology, University of Peshawar, Peshawar 25120, Khyber Pakhtunkhwa, Pakistan.ORCID 0009-0009-6469-1377 Sajjad AhmadInstitute of Pathology and Diagnostic Medicines, Khyber Medical University, Hayatabad, Peshawar 25100, Khyber Pakhtunkhwa, Pakistan.
Mubbashir HussainDepartment of Microbiology, Kohat University of Science and Technology, Kohat 26000, Khyber Pakhtunkhwa, Pakistan.ORCID 0000-0002-9828-0615 Susana CampinoFaculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK.
Taane G ClarkFaculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK.ORCID 0000-0001-8985-9265 Taj Ali KhanInstitute of Pathology and Diagnostic Medicines, Khyber Medical University, Hayatabad, Peshawar 25100, Khyber Pakhtunkhwa, Pakistan.
Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
backgroundResistance to first-line anti-tuberculosis drugs in
methodsWhole-genome sequencing was performed on 16 clinical isolates (12 MDR and 4 drug-susceptible) to identify resistance-associated mutations in
resultsA total of 16
conclusionsThis study suggests that the genetic landscape of drug resistance in
Indexed as
Antitubercular AgentsDrug Resistance, Multiple, BacterialMutationMycobacterium tuberculosisTuberculosis, Multidrug-ResistantBacterial ProteinsHumansMicrobial Sensitivity TestsPakistanPhylogenyWhole Genome SequencingAntitubercular AgentsBacterial Proteinsdrug-resistant tuberculosisMDR-TBMycobacterium tuberculosisphylogenetic analysiswhole-genome sequencing
Identifiers
PMID42198582
PMCPMC13209609
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