Evidence map›Paper›PMID 42198570›Full record

ArticleToxics2026

Morphological, Behavioral, and Transcriptomic Profiling Reveals Developmental Toxicity of PCB Metabolites in Zebrafish.

Nicole M Breese, Lisa Truong, Xueshu Li, Robyn L Tanguay, Hans-Joachim Lehmler

Abstract read
In one paragraph

Article in Toxics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Nicole M BreeseDepartment of Occupational and Environmental Health, College of Public Health, The University of Iowa, Iowa City, IA 52242, USA.
Lisa TruongSinnhuber Aquatic Research Laboratory, Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 97331, USA.ORCID 0000-0003-1751-4617
Xueshu LiDepartment of Occupational and Environmental Health, College of Public Health, The University of Iowa, Iowa City, IA 52242, USA.ORCID 0000-0002-0881-5381
Robyn L TanguaySinnhuber Aquatic Research Laboratory, Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 97331, USA.ORCID 0000-0001-6190-3682
Hans-Joachim LehmlerDepartment of Occupational and Environmental Health, College of Public Health, The University of Iowa, Iowa City, IA 52242, USA.ORCID 0000-0001-9163-927X

Funding

Training CoreP42ES013661 · NIEHS · UNIVERSITY OF IOWA · PI Keri C Hornbuckle · 2006 to 2026
$60.3M
Research Experience and Training Coordination CoreP42ES016465 · NIEHS · OREGON STATE UNIVERSITY · PI Robyn L Tanguay · 2009 to 2026
$52.5M
Discovering Chemical Activity Networks-Predicting Bioactivity Based on StructureR35ES031709 · NIEHS · OREGON STATE UNIVERSITY · PI Robyn L Tanguay · 2021 to 2026
$5.2M
NIEHS NIH HHS P42ES013661NIEHS NIH HHS P42ES016465NIEHS NIH HHS R35ES031709
6 · The paper itself

Abstract

Polychlorinated biphenyls (PCBs) persist in the environment as complex mixtures and undergo extensive biotransformation, yet the developmental toxicity of PCB metabolites remains poorly defined. We evaluated developmental, neurobehavioral, and molecular effects of parent PCBs, hydroxylated, methoxylated, and sulfated metabolites, and environmentally relevant mixtures using embryonic zebrafish. This study employed a high-throughput screening approach using nominal exposure concentrations to enable rapid hazard identification and prioritization across a large chemical series. Morphological abnormalities and photomotor behavior were assessed across early development, followed by targeted

Indexed as

metabolitesmixturesneurotoxicitypolychlorinated biphenylstranscriptomicszebrafish

Identifiers

PMID42198570
PMCPMC13211715

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.