Evidence map›Paper›PMID 42198511›Full record

ArticleToxics2026

Hepatic Mitochondrial Dysfunction and Gut Dysbiosis Induced by Polyethylene Microplastics in FVB/n Mice: A Comparative Study of Fluorescent and Non-Fluorescent Particles.

Mónica G Silva, Beatriz Medeiros-Fonseca, Adelina Gama, Isabel Gaivão, Sílvia Nunes, Mariana Fernandes, Paula A Oliveira, Vicente Monedero, Manuel Zúñiga, Maria Manuel Oliveira and 1 more

Abstract read
In one paragraph

Article in Toxics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Mónica G SilvaChemistry Research Centre (CQ-VR), University of Trás-os-Montes and Alto Douro (UTAD), 5000-801 Vila Real, Portugal.ORCID 0000-0003-0775-4457
Beatriz Medeiros-FonsecaCITAB-Centre for the Research and Technology of Agro-Environmental and Biological Sciences, University of Trás-os-Montes and Alto Douro (UTAD), 5000-801 Vila Real, Portugal.ORCID 0000-0002-3909-5903
Adelina GamaAnimal and Veterinary Research Centre (CECAV), University of Trás-os-Montes and Alto Douro (UTAD), 5000-801 Vila Real, Portugal.
Isabel GaivãoAnimal and Veterinary Research Centre (CECAV), University of Trás-os-Montes and Alto Douro (UTAD), 5000-801 Vila Real, Portugal.ORCID 0000-0003-4461-7021
Sílvia NunesFibEnTech-Fiber Materials and Environmental Technologies, University of Beira Interior, 6200-001 Covilhã, Portugal.
Mariana FernandesChemistry Research Centre (CQ-VR), University of Trás-os-Montes and Alto Douro (UTAD), 5000-801 Vila Real, Portugal.ORCID 0000-0001-6533-4309
Paula A OliveiraCITAB-Centre for the Research and Technology of Agro-Environmental and Biological Sciences, University of Trás-os-Montes and Alto Douro (UTAD), 5000-801 Vila Real, Portugal.ORCID 0000-0001-9519-4044
Vicente MonederoInstituto de Agroquímica y Tecnología de Alimentos, Calle Agustín Escardino 7, 46980 Paterna, Spain.ORCID 0000-0001-7461-8047
Manuel ZúñigaInstituto de Agroquímica y Tecnología de Alimentos, Calle Agustín Escardino 7, 46980 Paterna, Spain.
Maria Manuel OliveiraChemistry Research Centre (CQ-VR), University of Trás-os-Montes and Alto Douro (UTAD), 5000-801 Vila Real, Portugal.ORCID 0000-0001-5834-5253
Francisco PeixotoChemistry Research Centre (CQ-VR), University of Trás-os-Montes and Alto Douro (UTAD), 5000-801 Vila Real, Portugal.ORCID 0000-0001-9729-7477

Funding

Fundação para a Ciência e Tecnologia 2020-00805.CEEINDFundação para a Ciência e Tecnologia UI/BD/151320/2021Fundação para a Ciência e Tecnologia UID/00195/2025Fundação para a Ciência e Tecnologia UIDB/00616/2020 + UIDP/00616/2020Fundação para a Ciência e Tecnologia UID/PRR/00195/2025Fundação para a Ciência e Tecnologia UID/PRR2/00195/2025,
6 · The paper itself

Abstract

The emerging problem that microplastics pose to our society is reflected in the exponential growth in investigations devoted to uncovering their toxicological potential in humans. However, these studies present several limitations, one of the most significant being the use of microplastics that do not represent their environmental counterparts. In this study, we evaluated the impact of two types of polyethylene microplastics (27-32 µm)-non-fluorescent and fluorescent-on the liver and intestine, targeting mitochondria. FVB/n mice were subjected to a subacute exposure to two concentrations representative of human exposure (0.002% (

Indexed as

animal modelsmicroplasticsmitochondriapolyethylenetoxicology

Identifiers

PMID42198511
PMCPMC13211033

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.