Evidence map›Paper›PMID 42198346›Full record

ArticlePharmaceuticals (Basel, Switzerland)2026

Early Immune Signature Features, Including TLR2 and TLR4 Expression, Are Associated with Complete Remission After CD19 CAR-T Cell Therapy.

Serena Di Iasio, Chiara Di Nunzio, Elisabetta De Santis, Concetta Stella, Daniela Valente, Dalila Salvatore, Emanuela Merla, Grazia Dell'Olio, Costanzo Padovano, Mattia Colucci and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Serena Di IasioHematopathology Unit, Institute for Stem Cell Biology, Regenerative Medicine and Innovative Therapeutics (ISBReMIT), Fondazione IRCCS "Casa Sollievo della Sofferenza", Viale Padre Pio, 7, 71013 San Giovanni Rotondo, Italy.ORCID 0009-0007-1527-6498
Chiara Di NunzioHematopathology Unit, Institute for Stem Cell Biology, Regenerative Medicine and Innovative Therapeutics (ISBReMIT), Fondazione IRCCS "Casa Sollievo della Sofferenza", Viale Padre Pio, 7, 71013 San Giovanni Rotondo, Italy.ORCID 0000-0002-2107-9104
Elisabetta De SantisHematopathology Unit, Institute for Stem Cell Biology, Regenerative Medicine and Innovative Therapeutics (ISBReMIT), Fondazione IRCCS "Casa Sollievo della Sofferenza", Viale Padre Pio, 7, 71013 San Giovanni Rotondo, Italy.ORCID 0000-0002-6026-6797
Concetta StellaHematopathology Unit, Institute for Stem Cell Biology, Regenerative Medicine and Innovative Therapeutics (ISBReMIT), Fondazione IRCCS "Casa Sollievo della Sofferenza", Viale Padre Pio, 7, 71013 San Giovanni Rotondo, Italy.ORCID 0009-0002-4292-057X
Daniela ValenteDepartment of Hematology and Stem Cell Transplant Unit, Fondazione IRCCS "Casa Sollievo della Sofferenza", Viale Capuccini, 1, 71013 San Giovanni Rotondo, Italy.
Dalila SalvatoreDepartment of Hematology and Stem Cell Transplant Unit, Fondazione IRCCS "Casa Sollievo della Sofferenza", Viale Capuccini, 1, 71013 San Giovanni Rotondo, Italy.
Emanuela MerlaDepartment of Hematology and Stem Cell Transplant Unit, Fondazione IRCCS "Casa Sollievo della Sofferenza", Viale Capuccini, 1, 71013 San Giovanni Rotondo, Italy.
Grazia Dell'OlioDepartment of Hematology and Stem Cell Transplant Unit, Fondazione IRCCS "Casa Sollievo della Sofferenza", Viale Capuccini, 1, 71013 San Giovanni Rotondo, Italy.
Costanzo PadovanoHematopathology Unit, Institute for Stem Cell Biology, Regenerative Medicine and Innovative Therapeutics (ISBReMIT), Fondazione IRCCS "Casa Sollievo della Sofferenza", Viale Padre Pio, 7, 71013 San Giovanni Rotondo, Italy.
Mattia ColucciHematopathology Unit, Institute for Stem Cell Biology, Regenerative Medicine and Innovative Therapeutics (ISBReMIT), Fondazione IRCCS "Casa Sollievo della Sofferenza", Viale Padre Pio, 7, 71013 San Giovanni Rotondo, Italy.
Gaja BrunoHematopathology Unit, Institute for Stem Cell Biology, Regenerative Medicine and Innovative Therapeutics (ISBReMIT), Fondazione IRCCS "Casa Sollievo della Sofferenza", Viale Padre Pio, 7, 71013 San Giovanni Rotondo, Italy.ORCID 0009-0008-2320-2170
Barbara PasculliLaboratory of Oncology, Fondazione IRCCS "Casa Sollievo della Sofferenza", Viale Cappuccini, 1, 71013 San Giovanni Rotondo, Italy.ORCID 0000-0002-3333-0255
Mario CaldarelliDepartment of Translational Medicine and Surgery, Catholic University of Sacred Heart, Largo Agostino Gemelli, 8, 00168 Rome, Italy.ORCID 0000-0001-5308-7072
Paola ParrellaLaboratory of Oncology, Fondazione IRCCS "Casa Sollievo della Sofferenza", Viale Cappuccini, 1, 71013 San Giovanni Rotondo, Italy.ORCID 0000-0001-6031-9636
Giovanni GambassiDepartment of Translational Medicine and Surgery, Catholic University of Sacred Heart, Largo Agostino Gemelli, 8, 00168 Rome, Italy.
Rossella CianciDepartment of Translational Medicine and Surgery, Catholic University of Sacred Heart, Largo Agostino Gemelli, 8, 00168 Rome, Italy.ORCID 0000-0001-5378-8442
Angelo M CarellaDepartment of Hematology and Stem Cell Transplant Unit, Fondazione IRCCS "Casa Sollievo della Sofferenza", Viale Capuccini, 1, 71013 San Giovanni Rotondo, Italy.ORCID 0000-0002-4967-4204
Vincenzo GiambraHematopathology Unit, Institute for Stem Cell Biology, Regenerative Medicine and Innovative Therapeutics (ISBReMIT), Fondazione IRCCS "Casa Sollievo della Sofferenza", Viale Padre Pio, 7, 71013 San Giovanni Rotondo, Italy.ORCID 0000-0003-2607-2080

Funding

Italian Ministry of Health [T43-AN-01, "Bando Hub Scienza della Vita Regione Puglia" (POS) to V.G.]
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

&ampbiomarkersCAR-T cellscomplete remission (CR)DLBCLflow cytometryTLR4)Toll-like receptors 2 and 4 (TLR2&amp#x3B#xA0

Identifiers

PMID42198346
PMCPMC13209260

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.