Evidence map›Paper›PMID 42198282›Full record

ReviewPharmaceutics2026

Photo- and Immunotherapy Interface: Can Dendritic Cell Vaccines Overcome the Limitations of PDT?

Natalia Shilyagina, Yevgeniya Sannova, Victoria Turubanova, Irina Balalaeva

Abstract readReview
In one paragraph

Review in Pharmaceutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Natalia ShilyaginaInstitute of Biology and Biomedicine, Lobachevsky State University of Nizhny Novgorod, Nizhny Novgorod 603022, Russia.ORCID 0000-0001-5766-6880
Yevgeniya SannovaDepartment of Genetics and Life Sciences, Sirius University, Sochi 354340, Russia.
Victoria TurubanovaDepartment of Genetics and Life Sciences, Sirius University, Sochi 354340, Russia.ORCID 0000-0002-4648-0738
Irina BalalaevaInstitute of Biology and Biomedicine, Lobachevsky State University of Nizhny Novgorod, Nizhny Novgorod 603022, Russia.ORCID 0000-0002-3245-3907

Funding

Russian Science Foundation 24-75-10060
6 · The paper itself

Abstract

Photodynamic therapy (PDT) occupies an important place in the arsenal of cancer treatment modalities; however, its efficacy is primarily limited by the local nature of its effects and by tumor cell resistance. The aim of this review is to analyze the fundamental principles and biological consequences of PDT, to summarize current data on the molecular and cellular mechanisms determining its efficacy, and to consider strategies for overcoming its limitations. Particular attention is paid to the mechanisms underlying resistance development and to the role of switching from non-immunogenic to immunogenic cell death in shaping the antitumor response. The potential integration of PDT with dendritic cell vaccination is considered a promising strategy for overcoming these limitations. The potential of vaccine-based approaches to activate specific antitumor immunity in aggressive cancers is highlighted, with emphasis on the advantages of dendritic cell vaccines in addressing the limitations of conventional PDT.

Indexed as

antigen presentationantitumor effectapoptosisDAMPsferroptosisimmunogenic cell deathnecroptosisPDT resistancephotosensitizerpyroptosis

Identifiers

PMID42198282
PMCPMC13210220

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.