Evidence map›Paper›PMID 42198234›Full record

ReviewPharmaceutics2026

The Potential of Electrospun Meshes in Postoperative Pain Management.

Christodoulos Chrysanthou, Kenigen Manikion, Constantinos Voniatis

Abstract readReview
In one paragraph

Review in Pharmaceutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Christodoulos ChrysanthouLaboratory of Nanochemistry, Department of Biophysics and Radiation Biology, Semmelweis University, Tűzoltó Street 37-47, H-1094 Budapest, Hungary.
Kenigen ManikionLaboratory of Nanochemistry, Department of Biophysics and Radiation Biology, Semmelweis University, Tűzoltó Street 37-47, H-1094 Budapest, Hungary.ORCID 0009-0000-0585-2438
Constantinos VoniatisLaboratory of Nanochemistry, Department of Biophysics and Radiation Biology, Semmelweis University, Tűzoltó Street 37-47, H-1094 Budapest, Hungary.ORCID 0000-0002-5454-0120

Funding

János Bólyai Research Scholarship of the Hungarian Academy of Sciences no number
6 · The paper itself

Abstract

Postoperative pain management (POPM) remains a major clinical challenge despite its vital importance in reducing surgical stress, enabling early mobilization, and limiting postoperative complications. Conventional analgesic strategies are often constrained by short drug half-lives, repeated dosing requirements, systemic adverse effects, and the risk of opioid-related toxicity or dependence. These limitations suggest that the mode of drug delivery, in addition to drug selection itself, is a critical determinant of therapeutic performance. In this context, electrospun fibrous meshes represent a promising platform for localized and sustained analgesic delivery. Their high surface-area-to-volume ratio, tuneable porosity, broad polymer compatibility, and capacity to incorporate single or multiple bioactive agents make them attractive candidates for postoperative applications. This review summarizes recent advances in electrospun meshes for POPM, with particular emphasis on fabrication strategies, polymer selection, drug incorporation approaches, drug-release behaviour, biological performance, and translational challenges.

Indexed as

enhanced recoverynanotechnologysurgical implantsurgical regeneration

Identifiers

PMID42198234
PMCPMC13210733

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.