Evidence map›Paper›PMID 42198208›Full record

ReviewPharmaceutics2026

Trastuzumab Resistance, a Potential Roadblock for Most Successful Therapy of Breast Cancer-An Updated Review of Underlying Mechanisms, Clinical Trials and Patents to Evade the Resistance.

Gul Hasan, Soudipta Pramanik, Sandhya Singh, Pravin Gurav, Sudha Madhavi Penumaka, Sudheer Kumar, Debabrata Mandal

Abstract readReview
In one paragraph

Review in Pharmaceutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Gul HasanDepartment of Biotechnology, National Institute of Pharmaceutical Education and Research, Hajipur 844102, India.
Soudipta PramanikDepartment of Biotechnology, National Institute of Pharmaceutical Education and Research, Hajipur 844102, India.ORCID 0000-0001-6085-0662
Sandhya SinghDepartment of Biotechnology, National Institute of Pharmaceutical Education and Research, Hajipur 844102, India.
Pravin GuravDepartment of Biotechnology, National Institute of Pharmaceutical Education and Research, Hajipur 844102, India.
Sudha Madhavi PenumakaDepartment of Biotechnology, National Institute of Pharmaceutical Education and Research, Hajipur 844102, India.ORCID 0009-0001-6874-2401
Sudheer KumarDepartment of Biotechnology, National Institute of Pharmaceutical Education and Research, Hajipur 844102, India.
Debabrata MandalDepartment of Biotechnology, National Institute of Pharmaceutical Education and Research, Hajipur 844102, India.ORCID 0000-0001-6413-8509

Funding

Department of Pharmaceuticals Not applicable
6 · The paper itself

Abstract

Trastuzumab is the first humanised monoclonal antibody (Mab) developed for breast cancer (BC) therapy. The high affinity of Trastuzumab Fab-domain binding to the human epidermal growth factor receptor 2 (HER2) receptor, with a K

Indexed as

combination therapyHER2 receptorMucin1patents & clinical trialsPI3K/AKT/mTOR pathwaytrastuzumab resistance

Identifiers

PMID42198208
PMCPMC13210571

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.