ArticlePolymers2026
Surface Engineering of Electrospun PLA Fibers via Chitosan/Hyaluronic Acid Polyelectrolyte Complexes for Tunable Release of Rosmarinic Acid.
Article in Polymers, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
In this study, a hierarchical design strategy is introduced for tuning the release of rosmarinic acid (RA) from electrospun poly(L-lactide) (PLA) fibrous materials via surface engineering with chitosan/hyaluronic acid (Ch/HA) polyelectrolyte complexes (PECs). RA was selectively incorporated within the fiber bulk, the PEC coating, or both, enabling control over its spatial distribution. The PEC coating, formed by sequential dip coating, was shown to act as a diffusion-regulating layer with a dual role-either retarding RA release or promoting rapid initial release when functioning as a surface-associated reservoir. As a result, the release kinetics could be systematically tuned depending on the coating architecture and RA localization. Thorough characterization confirmed successful coating formation, enhanced surface hydrophilicity, and improved mechanical performance. All RA-loaded materials retained high antioxidant activity and exhibited pronounced antibacterial and antifungal effects against
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