ArticleSensors (Basel, Switzerland)2026
Label-Free Optical Sensor for Real-Time Monitoring of Insulin Secretion from Single Human Pancreatic Islets.
Article in Sensors (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Glucose-stimulated insulin secretion is the central functional readout of pancreatic islets, yet existing assays often require offline processing or pooling of multiple islets, limiting real-time assessment of single-islet function. Here we report a microscopy-compatible islet-on-a-chip (IOC) integrated with light scattering-based broadband backscattering confocal microscopy (BBCM) for continuous, label-free optical readout of insulin secretion dynamics in functional human islets. Fabricated using two-photon polymerization, the IOC-BBCM sensor stabilizes single human islets under continuous perfusion for high-resolution optical interrogation. The sensor identifies insulin-rich β-cells label-free, as confirmed by insulin immunostaining, and monitors granule depletion and redistribution during glucose and potassium chloride (KCl) stimulation, matching ELISA-quantified insulin secretion from the same perfused islets. This modular sensor provides a non-destructive, label-free approach for monitoring stimulus-linked secretion dynamics from individual human islets and should support longitudinal studies of islet function.
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