ArticlePlants (Basel, Switzerland)2026
Molecular Networking-Guided Phytochemical Profiling and Anti-Inflammatory Evaluation of Honglanqi, an Underutilized Commercial Specification of Astragali Radix.
Article in Plants (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Honglanqi (HLQ), a distinctive commercial specification of Astragali Radix (AR) characterized by rhytidome and interxylary cork, remains undervalued despite originating from premium long-cultivated material. The ethyl acetate fraction (HLQE) showed the greatest anti-inflammatory activity among the polarity-based fractions of an HLQ ethanol extract. We applied an integrated ultra-high performance liquid chromatography-quadrupole time-of-flight tandem mass spectrometry (UPLC-QTOF-MS/MS) and feature-based molecular networking (FBMN) strategy to systematically profile the chemical composition of HLQE. A total of 102 metabolites were annotated across seven compound classes, of which 18 were predicted as potential new compounds, and 37 were reported in AR for the first time. Three undescribed compounds, astragalinin A, astragalinin B, and astragquinone, were isolated and characterized, together with 19 known compounds. In LPS-stimulated RAW264.7 macrophages, astragalinin A exhibited potent inhibition of TNF-α and IL-6 (IC
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