ArticleMicroorganisms2026
Prebiotics Enhance Microbiome Recovery Following Antibiotic-Induced Dysbiosis.
Article in Microorganisms, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Microbiotherapy: an emerging adjunct for burn wound healing.Frontiers in cellular and infection microbiology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Antibiotic-induced dysbiosis disrupts gut microbiome diversity and functionality, often leading to negative health outcomes, including reduced short-chain fatty acid production, increased susceptibility to opportunistic pathogens, and an increased number of bacterial colonies exhibiting antibiotic resistance. This study investigates the effects of prebiotics (inulin-type fructans) and probiotic supplementation on microbiome recovery in a murine model. Broad spectrum antibiotics induced near-total microbiome depletion, significantly reducing microbial diversity and metabolite production. Prebiotic supplementation demonstrated superior efficacy during recovery in restoring microbiome diversity (~180 species), improving microbiome diversity metrics, and promoting metabolites, particularly butyrate and valerate, compared to probiotics or unmanipulated recovery. While effective in suppressing opportunistic bacterial growth, probiotics significantly delayed total microbial diversity recovery and resulted in lower diversity metrics (~50 species). However, prebiotic-treated microbiomes exhibited a wider antibiotic resistance profile in culturable bacteria, highlighting prebiotics' unique impact on the resistome. These findings underscore the potential of prebiotics for recovery from gut dysbiosis while emphasizing the need for further research to address safety considerations regarding their impacts on antibiotic resistance. Importance: This study explores the impact of prebiotic vs. probiotic manipulation of the microbiome in an antibiotic-induced dysbiosis mouse model. Our data demonstrate that prebiotics are more efficacious at enhancing total diversity and limiting the expansion of potentially harmful opportunist bacteria. This is the first study to indicate that prebiotics increase the number of culturable bacterial colonies resistant to antibiotics. These results contribute to our understanding of microbiome manipulation to promote health and limit disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.