ArticleMolecules (Basel, Switzerland)2026
Uncovering Bioactive Compounds in Propolis Extracts Prior to Isolation Through NMR Chemometric Analysis.
Article in Molecules (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Propolis is a resinous bee product with a long history of medicinal use, valued for its antimicrobial, antioxidant and anti-inflammatory properties. Identification of its key bioactive constituents would enable chemical standardization and quality control of propolis-based products, once their activity is confirmed. In the current study we investigated a Greek propolis sample (PR09) belonging to a phenolic-rich type, dominated by flavonoids. After extraction and fractionation with Fast Centrifugal Chromatography (FCPC), the fractions were evaluated for their DPPH and collagenase inhibitory activity while their NMR metabolic profiles were recorded. NMR HeteroCovariance Approach (NMR-HetCA) analysis of PR09 propolis methanolic extract revealed the presence of 26 secondary metabolites: seven diterpenes, 13 flavonoids and six caffeic acid esters. All compounds were identified from NMR-HetCA and Statistical Total Correlation Spectroscopy (STOCSY) plots prior to their isolation. NMR-HetCA analysis indicated that caffeic acid derivatives were the most potent inhibitors of the DPPH free radical and collagenase. Additionally, galangin (
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