Antimicrobial Peptide Papiliocin-Carbon Nanotube Hybrids: Potential Dual-Action Agents for Antimicrobial Activity and Apoptotic Cancer Cell Death.

Konstantinos Zacheilas, Myrto Margariti, Maria Apostolia Pissia, Rigini M Papi

Abstract read

In one paragraph

Article in Molecules (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

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2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Konstantinos ZacheilasLaboratory of Biochemistry, Department of Chemistry, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.ORCID 0009-0006-4248-0665

Myrto MargaritiLaboratory of Biochemistry, Department of Chemistry, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.

Maria Apostolia PissiaLaboratory of Food Chemistry and Technology, Department of Chemistry, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.ORCID 0000-0002-5354-5085

Rigini M PapiLaboratory of Biochemistry, Department of Chemistry, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.ORCID 0000-0002-3183-4724

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The emerging threat of antibiotic-resistant pathogens and the limitations that conventional cancer chemotherapies display have created an urgent need for the development of innovative therapeutic strategies. Combining the pleiotropic biological roles of antimicrobial peptides (AMPs) and nanomaterials through their conjugation presents a promising possibility of targeting both microbial membranes and malignant cells. In the present study, we engineered a novel bioactive material by immobilizing the insect-derived AMP Papiliocin onto multi-walled-decorated with polyethylene-glycol-carbon nanotubes (PEG-MWCNTs) to prevent proteolytic degradation of the peptide and enhance its cellular delivery. Recombinant Papiliocin was cloned, heterologously expressed, purified and conjugated onto the PEG-MWCNT carrier. Successful expression and conjugation were validated via immunoblotting and Fourier transform infrared (FT-IR) spectroscopy, respectively. Further physicochemical characterization of the bionanocomposites was conducted using Dynamic Light Scattering (DLS) and Zeta potential measurements. Biologically, the biofunctionalized material exhibited potent, broad-spectrum antimicrobial activity both on

Indexed as

Anti-Infective AgentsAntimicrobial Cationic PeptidesAntimicrobial PeptidesAntineoplastic AgentsApoptosisInsect ProteinsNanotubes, CarbonBiofilmsCandida albicansEscherichia coliHeLa CellsHumansMicrobial Sensitivity TestsPolyethylene GlycolsStaphylococcus aureusAnti-Infective AgentsAntimicrobial Cationic PeptidesAntimicrobial PeptidesAntineoplastic AgentsInsect ProteinsNanotubes, Carbonpapiliocin protein, Papilio xuthusPolyethylene Glycolsantimicrobial peptidesapoptosisCandida albicanscarbon nanotubescytotoxicitydelivery systemEscherichia coliHaCatHeLamicrobial resistancepapiliocinStaphylococcus aureus

Identifiers

PMID42197269

DOI10.3390/molecules31101715

PMCPMC13209427

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