Multi-Center Catalytic Oxidation of the Sotalol Drug Adsorbed on Gold Nanoparticles.

Ekaterina A Kolobova, Ksenia N Makarova, Elena V Solovyeva

Abstract read

In one paragraph

Article in Molecules (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

3 authors.

Ekaterina A KolobovaInstitute of Chemistry, Saint-Petersburg State University, Universitetskaya 7/9, 199034 Saint Petersburg, Russia.ORCID 0000-0001-6369-4511

Ksenia N MakarovaInstitute of Chemistry, Saint-Petersburg State University, Universitetskaya 7/9, 199034 Saint Petersburg, Russia.

Elena V SolovyevaInstitute of Chemistry, Saint-Petersburg State University, Universitetskaya 7/9, 199034 Saint Petersburg, Russia.ORCID 0000-0002-5046-3543

Funding

Russian Science Foundation 22-73-10052-P

6 · The paper itself

Abstract

Currently, gold nanoparticles are increasingly used in targeted drug delivery nanostructures. However, their intrinsic catalytic activity is often overlooked when using them as a carrier. In this study, the interaction between the sotalol drug from the beta-blocker family and gold nanoparticles was investigated using capillary electrophoresis and high-performance liquid chromatography. Both methods showed that sotalol undergoes catalytic oxidation on the surface of citrate-stabilized gold nanoparticles into three products. Together with a cleavage of the isopropyl group from the nitrogen atom, the oxidation at the hydroxyl group occurs with the formation of a ketone. Analysis of electropherograms showed 100% conversion of sotalol after 48 h of incubation at a surface coverage of 1.2 × 10

Indexed as

GoldMetal NanoparticlesSotalolAdsorptionCatalysisElectrophoresis, CapillaryOxidation-ReductionGoldSotalolbeta-blockerscapillary electrophoresisgold nanoparticlenanozymesurface reaction

Identifiers

PMID42197268

DOI10.3390/molecules31101714

PMCPMC13209385

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.