Evidence map›Paper›PMID 42197172›Full record

ArticleMolecules (Basel, Switzerland)2026

Structure-Function Correlations of Commercial Fucoidan Extracts: Antioxidant, Antiviral, Antifungal, Antibacterial and Prebiotic Activities.

Matthew Chadwick, Maria Sole Regina Lancerin, Patricia Hazelton, Kyriakos Vidalis, Emmanuel Petit, Paolina Lukova, Cédric Delattre, Xianfeng Chen, Thamarai Schneiders, Vasso Makrantoni and 2 more

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Matthew ChadwickInstitute for Bioengineering, The School of Engineering, The University of Edinburgh, Edinburgh EH9 3JL, UK.ORCID 0009-0003-4581-5457
Maria Sole Regina LancerinCentre for Inflammation Research, Institute of Regeneration and Repair, The University of Edinburgh, Edinburgh EH16 4UU, UK.
Patricia HazeltonInstitute for Bioengineering, The School of Engineering, The University of Edinburgh, Edinburgh EH9 3JL, UK.
Kyriakos VidalisCentre for Inflammation Research, Institute of Regeneration and Repair, The University of Edinburgh, Edinburgh EH16 4UU, UK.
Emmanuel PetitUMRT INRAe 1158 BioEcoAgro-BIOPI, IUT-GB, Université de Picardie Jules Verne, 80025 Amiens, France.ORCID 0000-0003-1533-6909
Paolina LukovaDepartment of Pharmacognosy and Pharmaceutical Chemistry, Faculty of Pharmacy, Medical University of Plovdiv, Vasil Aprilov Str. 15A, 4002 Plovdiv, Bulgaria.ORCID 0000-0003-2864-4388
Cédric DelattreInstitut Pascal, CNRS, Clermont Auvergne INP, Université Clermont Auvergne, 63000 Clermont-Ferrand, France.ORCID 0000-0003-3605-1929
Xianfeng ChenInstitute for Bioengineering, The School of Engineering, The University of Edinburgh, Edinburgh EH9 3JL, UK.ORCID 0000-0002-3189-2756
Thamarai SchneidersCentre for Inflammation Research, Institute of Regeneration and Repair, The University of Edinburgh, Edinburgh EH16 4UU, UK.
Vasso MakrantoniCentre for Inflammation Research, Institute of Regeneration and Repair, The University of Edinburgh, Edinburgh EH16 4UU, UK.ORCID 0000-0003-0668-6157
Richard SloanCentre for Inflammation Research, Institute of Regeneration and Repair, The University of Edinburgh, Edinburgh EH16 4UU, UK.
Simone DimartinoInstitute for Bioengineering, The School of Engineering, The University of Edinburgh, Edinburgh EH9 3JL, UK.ORCID 0000-0002-9695-1278

Funding

BioMara Ltd N/AEngineering and Physical Sciences Research Council 2796234
6 · The paper itself

Abstract

Fucoidan is a sulfated polysaccharide derived from brown seaweed, reported to possess diverse biological activities that make it a molecule of great interest for nutraceutical and biomedical applications. A significant challenge to its wider implementation is a lack of understanding of the relationship between fucoidan's structural and chemical characteristics with its biological activity. So far, approaches to identifying these relationships have been limited to qualitative comparisons of chemical and biological datasets or through chemically modified fucoidans. This work aimed to apply a formal methodology to elucidate potential relationships worthy of further exploration. The biological activity of commercial fucoidan extracts was assessed after detailed chemical characterization. The extracts exhibited multiple bioactivities, notably antioxidant activity, antiviral activity against Nipah virus, antifungal activity against

Indexed as

Anti-Bacterial AgentsAntifungal AgentsAntioxidantsAntiviral AgentsPolysaccharidesPrebioticsCandidaMicrobial Sensitivity TestsStructure-Activity RelationshipAnti-Bacterial AgentsAntifungal AgentsAntioxidantsAntiviral AgentsfucoidanPolysaccharidesPrebioticsantibacterialantifungalantioxidantantiviralbioactivityfucoidanprebioticstructurestructure–activity relationshipsulfation degree

Identifiers

PMID42197172
PMCPMC13209295

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.