Single-Molecule Chemistry Part II: Pathway Analysis of the Oxidation of Guanine to 8-Oxo-7,8-dihydroguanosine in an Oligonucleotide Hybrid.

Jens Sobek, Marco Schmidt, Stephan Landgraf, Aaron Fleming, Kiyohiko Kawai, Ralph Schlapbach

Abstract read

In one paragraph

Article in Molecules (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jens SobekFunctional Genomics Center Zurich, University and ETH Zurich, 8057 Zurich, Switzerland.

Marco SchmidtFunctional Genomics Center Zurich, University and ETH Zurich, 8057 Zurich, Switzerland.ORCID 0000-0003-4269-738X

Stephan LandgrafInstitute of Physical and Theoretical Chemistry, Graz University of Technology, 8010 Graz, Austria.ORCID 0000-0003-2255-6475

Aaron FlemingDepartment of Chemistry, University of Utah, Salt Lake City, UT 84112-0850, USA.

Kiyohiko KawaiDepartment of Life Science and Technology, School of Life Science and Technology, Institute of Science Tokyo, Yokohama 226-8501, Japan.ORCID 0000-0001-6845-0663

Ralph SchlapbachFunctional Genomics Center Zurich, University and ETH Zurich, 8057 Zurich, Switzerland.ORCID 0000-0002-7488-4262

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In a short 11 nt dye-labelled oligonucleotide hybrid, we investigated the oxidation of a single guanine, G, to 8-oxo-7,8-dihydroguanosine, 8oG, a reaction proceeding via two reaction pathways. In single-molecule fluorescence traces, we were able to detect the conversion of G to 8oG and assign different reaction pathways. Reactions are initiated by a photoinduced electron transfer to the dye, creating a G radical cation, G

Indexed as

GuanineGuanosineOligonucleotidesKineticsOxidation-Reduction8-hydroxyguanosineGuanineGuanosineOligonucleotidesCy3fluorescenceG oxidationhybridisationintermediatesoligonucleotidespathway analysissingle-molecule measurementSPRzero-mode waveguides

Identifiers

PMID42197118

DOI10.3390/molecules31101564

PMCPMC13210223

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.