Evidence map›Paper›PMID 42197028›Full record

Trial reportNutrients2026

Effects of γ-Aminobutyric Acid (GABA) Supplementation on Symptoms, Quality of Life, Intestinal Permeability, Systemic Inflammation and Gut Microbiota in Patients with IBS-D: A Randomized, Double Blind, Placebo-Controlled, Crossover Pilot Study.

Christian Lambiase, Lorenzo Cancelli, Riccardo Tedeschi, Antonio Grosso, Francesco Rettura, Rebecca Salemmo, Andrea Bottari, Fabio Filippini, Stefano Salvadori, Giulia Valdiserra and 5 more

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Nutrients, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Christian LambiaseGastrointestinal Unit, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, 56126 Pisa, Italy.
Lorenzo CancelliGastrointestinal Unit, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, 56126 Pisa, Italy.
Riccardo TedeschiGastrointestinal Unit, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, 56126 Pisa, Italy.
Antonio GrossoGastrointestinal Unit, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, 56126 Pisa, Italy.
Francesco RetturaGastroenterology Unit, Annunziata Hospital, Azienda Ospedaliera di Cosenza (AOCS), 87100 Cosenza, Italy.ORCID 0000-0003-3455-1794
Rebecca SalemmoGastrointestinal Unit, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, 56126 Pisa, Italy.
Andrea BottariGastrointestinal Unit, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, 56126 Pisa, Italy.ORCID 0000-0001-5343-7271
Fabio FilippiniRetrovirus Center, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, 56126 Pisa, Italy.ORCID 0009-0006-3309-763X
Stefano SalvadoriInstitute of Clinical Physiology, National Research Council, 56124 Pisa, Italy.ORCID 0000-0002-1266-3931
Giulia ValdiserraUnit of Pharmacology and Pharmacovigilance, Department of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, Italy.
Letizia CampigliUnit of Pharmacology and Pharmacovigilance, Department of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, Italy.ORCID 0009-0000-9443-9919
Luca AntonioliUnit of Pharmacology and Pharmacovigilance, Department of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, Italy.
Matteo FornaiUnit of Pharmacology and Pharmacovigilance, Department of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, Italy.ORCID 0000-0002-0812-3959
Nicola de BortoliGastrointestinal Unit, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, 56126 Pisa, Italy.ORCID 0000-0003-1995-1060
Massimo BelliniGastrointestinal Unit, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, 56126 Pisa, Italy.ORCID 0000-0002-6387-6443

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Dietary Supplementsgamma-Aminobutyric AcidGastrointestinal MicrobiomeIrritable Bowel SyndromeQuality of LifeAdultCross-Over StudiesDiarrheaDouble-Blind MethodFemaleHumansInflammationInterleukin-1betaIntestinal Barrier FunctionIntestinal MucosaMalegamma-Aminobutyric AcidInterleukin-1betaMembrane GlycoproteinsTumor Necrosis Factor-alphaGABAIBSirritable bowel syndromeγ-aminobutyric acid

Identifiers

PMID42197028
PMCPMC13209747

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.