ArticleNutrients2026
Enhancing Quercetin Bioavailability Attenuates Aging Phenotypes via the Gut Microbiota-Intestinal Barrier Axis in Aged Mice.
Article in Nutrients, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Effects of Plant Polyphenols on Obesity-Induced Inflammatory Depression: A Review.International journal of molecular sciences · 2026Review
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4 authors.
Funding
Abstract
BACKGROUND/
objectivesAging is characterized by progressive functional decline associated with alterations in gut microbiota, epithelial barrier dysfunction, and cellular senescence. Although quercetin has been proposed as a potential anti-aging compound, its clinical application is limited by poor bioavailability. In this study, we investigated whether enhancing quercetin bioavailability using EubioQuercetin (EQN) modulates aging-related phenotypes through the gut microbiota-intestinal barrier axis.
methodsMale C57BL/6J mice were treated with EQN or conventional quercetin (CQN) for 12 weeks. External aging phenotypes were assessed using a composite aging score based on hair glossiness, hair loss, and the presence of white hair. Gut microbiota composition was analyzed via 16S rRNA sequencing with centered log-ratio transformation, and intestinal gene expression was assessed by quantitative reverse transcription-polymerase chain reaction.
resultsEQN significantly reduced the aging score compared with the control group (median 4.5 vs. 8,
conclusionsThese findings indicate that enhancing quercetin bioavailability attenuates externally assessed aging phenotypes in aged mice and is associated with coordinated changes in gut microbiota and intestinal gene expression. Modulation of the gut microbiota-intestinal barrier axis may represent a potential mechanism underlying these effects.
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