Evidence map›Paper›PMID 42196942›Full record

ArticleNutrients2026

Protein Restriction Increases Soluble Leptin Receptor via a Leptin-Dependent Mechanism Without Affecting Leptin-Induced Appetite Suppression in Mice.

Mizuki Uchiyama, Tamaki Toyama, Yu Takei, Hinata Ishii, Asako Takenaka

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mizuki UchiyamaDepartment of Agricultural Chemistry, School of Agriculture, Meiji University, Kawasaki 214-8571, Kanagawa, Japan.
Tamaki ToyamaDepartment of Agricultural Chemistry, School of Agriculture, Meiji University, Kawasaki 214-8571, Kanagawa, Japan.
Yu TakeiDepartment of Agricultural Chemistry, School of Agriculture, Meiji University, Kawasaki 214-8571, Kanagawa, Japan.
Hinata IshiiDepartment of Agricultural Chemistry, School of Agriculture, Meiji University, Kawasaki 214-8571, Kanagawa, Japan.
Asako TakenakaDepartment of Agricultural Chemistry, School of Agriculture, Meiji University, Kawasaki 214-8571, Kanagawa, Japan.ORCID 0000-0002-4125-7019

Funding

Japan Society for the Promotion of Science Grant Numbers 19H02916 and 22H02291
6 · The paper itself

Abstract

BACKGROUND/

objectivesLeptin, an adipocyte-derived hormone, suppresses appetite and regulates adiposity. Its soluble receptor (sOb-R), generated from the extracellular domain of the leptin receptor (Ob-R), circulates as a leptin-binding protein. We previously demonstrated that dietary protein restriction increased hepatic

methodsC57BL/6J and

resultsProtein restriction increased hepatic

conclusionsProtein restriction elevates circulating sOb-R through a leptin-dependent mechanism; however, this increase does not modify leptin-induced appetite suppression. These findings provide insight into the regulation of sOb-R under protein-restricted conditions.

Indexed as

AppetiteAppetite RegulationDiet, Protein-RestrictedLeptinReceptors, LeptinAnimalsLiverMaleMiceMice, Inbred C57BLMice, ObeseRNA, MessengerLeptinleptin receptor, mouseReceptors, LeptinRNA, Messengerleptinleptin receptorOb-Rprotein restrictionsoluble Ob-R

Identifiers

PMID42196942
PMCPMC13209210

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.