ArticleInternational journal of environmental research and public health2026
Public Knowledge and Attitudes Towards Clinical Trial Participation: A Mixed-Method Study in Bagamoyo District, Tanzania.
Article in International journal of environmental research and public health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundClinical trials are important for advancing medical knowledge and improving healthcare delivery. However, participants' knowledge and attitudes towards clinical trials remain a key challenge affecting clinical trial recruitment and participant retention. Therefore, this study aimed to assess the knowledge and attitudes of the Bagamoyo district towards participation in clinical trials.
methodsA convergent parallel mixed-methods study was conducted among adults in the Bagamoyo district. Multistage stratified random sampling was used to select participants. Quantitative data were analysed descriptively and using logistic regression, while qualitative data were analysed thematically using NVivo.
resultsAmong 394 recruited participants, 293 (74.4%) were female and 101 (25.6%) were male. Most participants had a primary-level education (266, 67.5%), while 128 (32.5%) had secondary or tertiary education. The majority were married (297, 75.4%) and 97 (24.6%) were either separated or unmarried. Regarding economic status, 244 participants (61.9%) earned less than TZS 50,000. General knowledge of clinical trials was low, with most participants scoring below 60%. However, we found a positive attitude towards participation in clinical trials. Logistic regression revealed that poor knowledge was significantly associated with being male (AOR, 22.95 (95% CI: 10.27-51.28,
conclusionsDespite low levels of knowledge, the general population in the Bagamoyo district demonstrated a high willingness to participate in clinical trials. To address the knowledge gap, targeted educational interventions should focus on older adults and the unemployed. Furthermore, policies supporting community outreach and awareness campaigns may help strengthen public understanding and sustain positive attitudes toward clinical research.
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