ArticleInternational journal of molecular sciences2026
Transient Overexpression of pVHL Mediated by Adenoviral Vector Injection in Pancreatic Tissue Decreases Blood Glucose Levels in a Hypercaloric Diet-Induced Mouse Model of Type 2 Diabetes Mellitus.
Alma N Díaz-Herreros, Elba Reyes-Maldonado, Erika Rosales-Cruz, Fernando Gómez-Chávez, Amaranta Sarai Valdez-Guerrero, Octavio Rodríguez-Cortés, Juan C Cancino-Díaz, Mario E Cancino-Díaz
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In one paragraphArticle in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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8 authors.
Alma N Díaz-HerrerosLaboratorio de Inmunología Aplicada, Departamento de Inmunología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Mexico City 11340, Mexico.ORCID 0000-0001-6058-6611 Elba Reyes-MaldonadoLaboratorio de Hematología, Departamento de Morfología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Mexico City 11340, Mexico.
Erika Rosales-CruzLaboratorio de Hematología, Departamento de Morfología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Mexico City 11340, Mexico.
Fernando Gómez-ChávezLaboratorio de Enfermedades Osteoarticulares e Inmunológicas, Sección de Estudios de Posgrado e Investigación, Escuela Nacional de Medicina y Homeopatía, Instituto Politécnico Nacional, Mexico City 07320, Mexico.ORCID 0000-0002-5050-2143 Amaranta Sarai Valdez-GuerreroLaboratorio de Bioquímica Aplicada, Escuela Superior de Medicina, Instituto Politécnico Nacional, Mexico City 11340, Mexico.
Octavio Rodríguez-CortésLaboratorio de Inflamación y Obesidad, Escuela Superior de Medicina, Instituto Politécnico Nacional, Mexico City 11340, Mexico.
Juan C Cancino-DíazLaboratorio de Inmunomicrobiología, Departamento de Microbiología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Mexico City 11340, Mexico.
Mario E Cancino-DíazLaboratorio de Inmunología Aplicada, Departamento de Inmunología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Mexico City 11340, Mexico.ORCID 0000-0003-0271-7892 Funding
Instituto Politécnico Nacional SIP-20253840Instituto Politécnico Nacional SIP-20260895
6 · The paper itselfAbstract
The VHL-HIF-1α-VEGF axis regulates angiogenesis and metabolism. Beyond oncology, pVHL is essential for pancreatic β-cell function and is reduced in hypercaloric diet (HCD)-induced type 2 diabetes mellitus (T2DM). This study aimed to overexpress pVHL in pancreatic tissue and evaluate its effects on blood glucose levels and the expression of proteins related to glucose metabolism in the pancreas. HCD-induced diabetic C57BL/6 and BALB/c mice received a single intrapancreatic injection of an adenoviral vector (1 × 10
Indexed as
AdenoviridaeBlood GlucoseDiabetes Mellitus, ExperimentalDiabetes Mellitus, Type 2Genetic VectorsPancreasVon Hippel-Lindau Tumor Suppressor ProteinAnimalsDisease Models, AnimalGlucose Transporter Type 1Glucose Transporter Type 2Hypoxia-Inducible Factor 1, alpha SubunitInsulinMaleMiceMice, Inbred BALB CBlood GlucoseGlucose Transporter Type 1Glucose Transporter Type 2Hif1a protein, mouseHypoxia-Inducible Factor 1, alpha SubunitInsulinVon Hippel-Lindau Tumor Suppressor Proteinadenoviral vectorGLUT-1GLUT-2HIF-1αinsulinpancreatic tissuepVHLtype 2 diabetes mellitusVHL–HIF-1α axis
Identifiers
PMID42196617
PMCPMC13206921
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