Evidence map›Paper›PMID 42196614›Full record

ArticleInternational journal of molecular sciences2026

GM-CSF Promotes Superior In Vitro Differentiation of MHC II

Gabriel Cordeiro, Felipe Cezar Pinheiro de Mato, Amanda Pires Bonfanti, Liana Verinaud, Catarina Rapôso

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Gabriel CordeiroLaboratory of Immunopatologies, Departament of Microbiology and Immunology, Institute of Biology, Universidade Estadual de Campinas, Campinas 13083-970, Brazil.ORCID 0000-0001-8740-0397
Felipe Cezar Pinheiro de MatoLaboratory of Immunopatologies, Departament of Microbiology and Immunology, Institute of Biology, Universidade Estadual de Campinas, Campinas 13083-970, Brazil.
Amanda Pires BonfantiLaboratory of Immunopatologies, Departament of Microbiology and Immunology, Institute of Biology, Universidade Estadual de Campinas, Campinas 13083-970, Brazil.ORCID 0000-0003-0896-0105
Liana VerinaudLaboratory of Immunopatologies, Departament of Microbiology and Immunology, Institute of Biology, Universidade Estadual de Campinas, Campinas 13083-970, Brazil.ORCID 0000-0003-4247-8128
Catarina RapôsoLaboratory of Immunopatologies, Departament of Microbiology and Immunology, Institute of Biology, Universidade Estadual de Campinas, Campinas 13083-970, Brazil.

Funding

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior #158888/2018-9Foundation for the Development of Unicamp #2230/24Fundação de Amparo à Pesquisa do Estado de São Paulo #2015/04194-0Fundação de Amparo à Pesquisa do Estado de São Paulo #2022/03543-4
6 · The paper itself

Abstract

Antigen-presenting cells (APCs) play a critical role in modulating immune responses, making the optimization of their differentiation protocols essential for advancing cell-based immunotherapies. This study evaluated eight protocols to differentiate APCs from bone marrow precursors of C57BL/6J mice, comparing the effects of GM-CSF and L-929 conditioned supernatants at various concentrations. Four groups treated with GM-CSF and four with L-929 supernatant, alongside a control group, were assessed. Flow cytometry analysis revealed that GM-CSF significantly increased the yield of CD11c

Indexed as

Antigen-Presenting CellsBone Marrow CellsCD11c AntigenCell DifferentiationGranulocyte-Macrophage Colony-Stimulating FactorHistocompatibility Antigens Class IIAnimalsCells, CulturedCulture Media, ConditionedMiceMice, Inbred C57BLCD11c AntigenCulture Media, ConditionedGranulocyte-Macrophage Colony-Stimulating FactorHistocompatibility Antigens Class IIC57BL/6Jdendritic cellmacrophageprotocol comparisonstem cell

Identifiers

PMID42196614
PMCPMC13207752

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.