Evidence map›Paper›PMID 42196605›Full record

ArticleInternational journal of molecular sciences2026

Protonation States of Proton-Sensing Glutamate Residues in Transporter Sialin.

Eric Wooten, Nara L Chon, Muhamadjon Dzhalolov, Hongjin Zheng, Hai Lin

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Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Eric WootenDepartment of Chemistry, University of Colorado Denver, Denver, CO 80217, USA.
Nara L ChonDepartment of Chemistry, University of Colorado Denver, Denver, CO 80217, USA.
Muhamadjon DzhalolovDepartment of Chemistry, University of Colorado Denver, Denver, CO 80217, USA.ORCID 0009-0003-0931-0021
Hongjin ZhengDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.ORCID 0000-0001-5324-6264
Hai LinDepartment of Chemistry, University of Colorado Denver, Denver, CO 80217, USA.ORCID 0000-0002-3525-9122

Funding

Mechanistic studies of human transporter SialinR01HL168686 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI ZHENG, HONGJIN · 2024 to 2025
$1.7M
Mechanistic studies of essential membrane transportersR35GM151970 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI Hongjin Zheng · 2024 to 2026
$1.0M
NHLBI NIH HHS R01 HL168686NIGMS NIH HHS R35 GM151970NIH HHS 1R01HL168686-01A1NIH HHS 1R35GM151970-01
6 · The paper itself

Abstract

Sialic acids are a diverse class of widely distributed monosaccharides that are engaged in a wide range of biological processes. Sialin, a sialic acid/proton symporter, transports sialic acid across membranes between the lysosomal lumen and cytosol, playing a critical role in sialin metabolism. Taking advantage of recently published experimental structures of sialin, we report here the first computational study that probes the molecular mechanism of ligand transport through sialin, which is yet to be fully understood. In particular, we carry out steered molecular dynamics simulations of the transport of

Indexed as

Glutamic AcidOrganic Anion TransportersProtonsSymportersMolecular Dynamics SimulationMutationN-Acetylneuraminic AcidGlutamic AcidN-Acetylneuraminic AcidOrganic Anion TransportersProtonssialic acid transport proteinsSymportersarginine-to-lysine mutationcontinuum solvation modelsalt bridgesialic acidsteered molecular dynamics

Identifiers

PMID42196605
PMCPMC13207226

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.