Effects of Inhaled Corticosteroids and Long-Acting β2-Agonists on Efferocytosis and Inflammatory Cell Survival: An In Vitro Study Relevant to COPD and Lung Cancer.

Bassam Redwan, Christian Biancosino, Stefan Fischer, Sabina Janciauskiene, Heiko Golpon

Abstract read

In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Bassam RedwanDepartment of Thoracic Surgery, Knappschaft Kliniken Gelsenkirchen Buer, Schernerweg 4, 45894 Gelsenkirchen, Germany.

Christian BiancosinoHelios University Hospital Wuppertal, University of Witten/Herdecke, 42283 Wuppertal, Germany.

Stefan FischerDepartment of Thoracic Surgery and Lung Assist, Klinikum Ibbenbüren, 49477 Ibbenbüren, Germany.

Sabina JanciauskieneDepartment of Respiratory Medicine, Hannover Medical School (MHH), Carl-Neuberg-Straße 1, 30625 Hannover, Germany.ORCID 0000-0001-7687-5258

Heiko GolponDepartment of Respiratory Medicine, Hannover Medical School (MHH), Carl-Neuberg-Straße 1, 30625 Hannover, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Efferocytosis-the tightly regulated clearance of apoptotic cells by phagocytes-maintains tissue homeostasis and is impaired in chronic obstructive pulmonary disease (COPD), where it contributes to persistent inflammation and increases the risk of comorbidities, including lung cancer. Inhaled corticosteroids (ICS) and long-acting β2 agonists (LABAs) are cornerstones of COPD therapy, but their effects on efferocytosis and on the COPD-lung cancer interface are incompletely understood. The primary objective of this study was to determine whether the ICS fluticasone propionate and the LABA salmeterol xinafoate, alone or in combination at clinically informed concentrations (10

Indexed as

Adrenal Cortex HormonesAdrenergic beta-2 Receptor AgonistsEfferocytosisLung NeoplasmsPulmonary Disease, Chronic ObstructiveA549 CellsAdministration, InhalationAnimalsApoptosisCell SurvivalFluticasoneHumansInflammationJurkat CellsMiceNeutrophilsAdrenal Cortex HormonesAdrenergic beta-2 Receptor AgonistsFluticasoneSalmeterol XinafoateapoptosisCOPDefferocytosisfluticasone propionateinhaled corticosteroidslong-acting β2 agonistslung cancermacrophagesneutrophilsphagocytosissalmeterol xinafoatetumor microenvironment

Identifiers

PMID42196603

DOI10.3390/ijms27104627

PMCPMC13206938

What OpenQuestion holds

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LicenceCC BY

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.