Evidence map›Paper›PMID 42196587›Full record

ArticleInternational journal of molecular sciences2026

Synergy Between the Auranofin Analogue PEt

Beatrice Amato, Diletta Mazzantini, José Aleixo de Azevedo-França, Giuseppantonio Maisetta, Emilia Ghelardi, Semih Esin, Luigi Messori, Giovanna Batoni

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Beatrice AmatoDepartment of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, 56126 Pisa, Italy.
Diletta MazzantiniDepartment of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, 56126 Pisa, Italy.ORCID 0000-0002-7747-8200
José Aleixo de Azevedo-FrançaDepartment of Chemistry, University of Florence, 50019 Florence, Italy.ORCID 0000-0002-9387-9215
Giuseppantonio MaisettaDepartment of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, 56126 Pisa, Italy.
Emilia GhelardiDepartment of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, 56126 Pisa, Italy.ORCID 0000-0001-6863-1384
Semih EsinDepartment of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, 56126 Pisa, Italy.ORCID 0000-0002-4358-5294
Luigi MessoriDepartment of Chemistry, University of Florence, 50019 Florence, Italy.ORCID 0000-0002-9490-8014
Giovanna BatoniDepartment of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, 56126 Pisa, Italy.ORCID 0000-0002-4448-2385

Funding

European Union-Next Generation EU within the National Recovery and Resilience Plan (PNRR) THE-Tuscany Health Ecosystem, Spoke 7-Innovating Translational Medi-cine-Subproject 5-Innovative models for management of infections caused by antibi-otic-resistant Project code: ECS00000017; CUP I53C22000780001
6 · The paper itself

Abstract

Auranofin (AF), an FDA-approved drug for rheumatoid arthritis, exhibits strong antibacterial activity against Gram-positive bacteria, while Gram-negative species remain largely tolerant. This study assessed the antimicrobial activity of AF and three analogues against clinically relevant Gram-negative pathogens and explored tolerance mechanisms in

Indexed as

Anti-Bacterial AgentsAuranofinGlutathionePseudomonas aeruginosaDrug SynergismMicrobial Sensitivity TestsPolymyxin BAnti-Bacterial AgentsAuranofinGlutathionePolymyxin Bauranofinauranofin analoguedrug repurposinggold conjugatesPEt3AuClPseudomonas aeruginosatolerance mechanisms

Identifiers

PMID42196587
PMCPMC13207821

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.