Evidence map›Paper›PMID 42196503›Full record

ArticleInternational journal of molecular sciences2026

Phosphonamidates Integrating Sterically Hindered Phenols with Membrane-Active Cations: A Redox-Activated Approach to Antimicrobial Agents.

Elmira Gibadullina, Adel Shakirov, Margarita Neganova, Yulia Aleksandrova, Alexandra Voloshina, Anna Lyubina, Anastasiya Sapunova, Anna Strelnik, Kamil Ivshin, Assel Shuragaziyeva and 5 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Elmira GibadullinaArbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences, Akad. Arbuzov St. 8, Kazan 420088, Russia.ORCID 0000-0003-2615-9418
Adel ShakirovArbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences, Akad. Arbuzov St. 8, Kazan 420088, Russia.ORCID 0009-0009-3223-2491
Margarita NeganovaLaboratory of Engineering Profile "Physical and Chemical Methods of Analysis", Korkyt Ata Kyzylorda University, 29A, Aiteke Bi Street, Kyzylorda 120014, Kazakhstan.ORCID 0000-0001-9346-5920
Yulia AleksandrovaLaboratory of Engineering Profile "Physical and Chemical Methods of Analysis", Korkyt Ata Kyzylorda University, 29A, Aiteke Bi Street, Kyzylorda 120014, Kazakhstan.ORCID 0000-0002-5370-3370
Alexandra VoloshinaArbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences, Akad. Arbuzov St. 8, Kazan 420088, Russia.
Anna LyubinaArbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences, Akad. Arbuzov St. 8, Kazan 420088, Russia.ORCID 0000-0002-2816-8142
Anastasiya SapunovaArbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences, Akad. Arbuzov St. 8, Kazan 420088, Russia.
Anna StrelnikArbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences, Akad. Arbuzov St. 8, Kazan 420088, Russia.
Kamil IvshinArbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences, Akad. Arbuzov St. 8, Kazan 420088, Russia.ORCID 0000-0002-9720-7977
Assel ShuragaziyevaLaboratory of Engineering Profile "Physical and Chemical Methods of Analysis", Korkyt Ata Kyzylorda University, 29A, Aiteke Bi Street, Kyzylorda 120014, Kazakhstan.ORCID 0000-0001-6774-7449
Altynkul ToibazarovaLaboratory of Engineering Profile "Physical and Chemical Methods of Analysis", Korkyt Ata Kyzylorda University, 29A, Aiteke Bi Street, Kyzylorda 120014, Kazakhstan.ORCID 0000-0002-9902-2546
Banu DiyarovaDepartment of Chemistry, Institute of Natural Science, Kazakh National Women's Teacher Training University, 144/8 Gogol Street, Almaty 050000, Kazakhstan.
Anipa TapalovaLaboratory of Engineering Profile "Physical and Chemical Methods of Analysis", Korkyt Ata Kyzylorda University, 29A, Aiteke Bi Street, Kyzylorda 120014, Kazakhstan.
Nurbol AppazovLaboratory of Engineering Profile "Physical and Chemical Methods of Analysis", Korkyt Ata Kyzylorda University, 29A, Aiteke Bi Street, Kyzylorda 120014, Kazakhstan.ORCID 0000-0001-8765-3386
Alexander BurilovArbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences, Akad. Arbuzov St. 8, Kazan 420088, Russia.ORCID 0000-0003-2938-7352

Funding

Ministry of Science and Higher Education of the Republic of Kazakhstan AP23490056
6 · The paper itself

Abstract

A strategy to create highly effective antimicrobial agents was proposed based on the conjugation of three functional components: a cationic quaternary ammonium salt (QAS) that exerts a membrane-disrupting effect and promotes selective accumulation on bacterial surfaces; a phosphonamidate linker for controlled activation; and a sterically hindered phenol (SHP) fragment as a potential redox component. This approach enabled the preparation of 40 target phosphonamidate-SHP/QAS hybrids in high yields (88-98%). Evaluation of their antimicrobial activity against major pathogens and methicillin-resistant

Indexed as

Anti-Bacterial AgentsAnti-Infective AgentsPhenolsCationsGram-Positive BacteriaHumansMethicillin-Resistant Staphylococcus aureusMicrobial Sensitivity TestsOxidation-ReductionQuaternary Ammonium CompoundsReactive Oxygen SpeciesAnti-Bacterial AgentsAnti-Infective AgentsCationsPhenolsQuaternary Ammonium CompoundsReactive Oxygen Speciesantimicrobial activitybacterial resistancecytotoxicity profileMRSAphosphonamidatesquaternary ammonium saltsquinone methideredox activationsterically hindered phenolsstructure-activity relationship

Identifiers

PMID42196503
PMCPMC13207327

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.