ArticleInternational journal of molecular sciences2026
Integrated Genomic Profiling of Pediatric Acute Lymphoblastic Leukemia: Genomic Landscape, Risk Stratification and Association of RAS Pathway Mutations with Early Treatment Response.
Andreea Stefan-Hodorogea, Letitia Radu, Andra Marcu, Andreea Serbanica, Ana Bica, Cristina Jercan, Ana Marcu, Dumitru Jardan, Cerasela Jardan, Onda Calugaru and 6 more
Abstract read
In one paragraphArticle in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
16 authors.
Andreea Stefan-HodorogeaFaculty of General Medicine, "Carol Davila" University of Medicine and Pharmacy, 020022 Bucharest, Romania.
Letitia RaduFaculty of General Medicine, "Carol Davila" University of Medicine and Pharmacy, 020022 Bucharest, Romania.ORCID 0000-0003-1677-5479 Andra MarcuFaculty of General Medicine, "Carol Davila" University of Medicine and Pharmacy, 020022 Bucharest, Romania.ORCID 0000-0003-3706-6620 Andreea SerbanicaFaculty of General Medicine, "Carol Davila" University of Medicine and Pharmacy, 020022 Bucharest, Romania.
Ana BicaFaculty of General Medicine, "Carol Davila" University of Medicine and Pharmacy, 020022 Bucharest, Romania.
Cristina JercanFaculty of General Medicine, "Carol Davila" University of Medicine and Pharmacy, 020022 Bucharest, Romania.ORCID 0000-0001-9039-5859 Ana MarcuFaculty of General Medicine, "Carol Davila" University of Medicine and Pharmacy, 020022 Bucharest, Romania.
Dumitru JardanMolecular Biology Laboratory, Medlife Clinic, Calea Grivitei No. 371, 012244 Bucharest, Romania.
Cerasela JardanFaculty of General Medicine, "Carol Davila" University of Medicine and Pharmacy, 020022 Bucharest, Romania.
Onda CalugaruFaculty of General Medicine, "Carol Davila" University of Medicine and Pharmacy, 020022 Bucharest, Romania.
Codruta PopaFaculty of General Medicine, "Carol Davila" University of Medicine and Pharmacy, 020022 Bucharest, Romania.ORCID 0000-0002-7638-3285 Anca GheorgheFlow Cytometry Laboratory, Fundeni Clinical Institute, 022328 Bucharest, Romania.
Karina VihtaMolecular Biology Laboratory, Medlife Clinic, Calea Grivitei No. 371, 012244 Bucharest, Romania.ORCID 0000-0002-4111-7577 Simona DimaFaculty of General Medicine, "Carol Davila" University of Medicine and Pharmacy, 020022 Bucharest, Romania.
Anca ColitaFaculty of General Medicine, "Carol Davila" University of Medicine and Pharmacy, 020022 Bucharest, Romania.ORCID 0000-0001-6031-8190 Funding
Ministry of Research and Innovation EU NextGenerationEU instrument through the National Recovery and Resilience Plan of Romania - Pillar III-C9-I, section I5. Establishment and operationalization of Competence Centers PNRR-III-C9-2022 - I5, within the project entitled "Creation, Operational
6 · The paper itselfAbstract
Acute lymphoblastic leukemia (ALL) is the most common pediatric malignancy and genomic profiling has become increasingly vital for risk stratification. We conducted a retrospective single-center study including 96 newly diagnosed pediatric patients with ALL and mixed phenotype acute leukemia to characterize the genomic landscape using conventional and molecular cytogenetics, multiplex ligation-dependent probe amplification and targeted next-generation sequencing and to evaluate associations with treatment response and survival. Mutation co-occurrence analysis revealed a NRAS/KRAS/JAK cluster and an
Indexed as
MutationPrecursor Cell Lymphoblastic Leukemia-Lymphomaras ProteinsAdolescentChildChild, PreschoolFemaleGenomicsHigh-Throughput Nucleotide SequencingHumansInfantMaleRetrospective StudiesSignal TransductionTreatment Outcomeras Proteinsacute lymphoblastic leukemianext-generation sequencingRAS pathway mutations
Identifiers
PMID42196495
PMCPMC13207613
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