Evidence map›Paper›PMID 42196483›Full record

ArticleInternational journal of molecular sciences2026

Nrf2 Is Associated with Metastasis-Related Processes in a Chemoresistant Breast Cancer Model: Insights from siRNA Modulation.

Andrea Muñoz-Ayala, Nicolás Serafín-Higuera, Ana Gabriela Leija-Montoya, Octavio Galindo-Hernández, José Luis Vique-Sánchez, Raúl Díaz-Molina, Santiago Villafaña, Victor García-González

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Andrea Muñoz-AyalaFacultad de Medicina y Nutrición Mexicali, Universidad Autónoma de Baja California, Humberto Torres Sanginés S/N, Centro Cívico, Mexicali 21000, BC, Mexico.ORCID 0009-0007-2715-9811
Nicolás Serafín-HigueraFacultad de Odontología Mexicali, Universidad Autónoma de Baja California, Mexicali 21000, BC, Mexico.ORCID 0000-0002-0402-3985
Ana Gabriela Leija-MontoyaCentro de Ciencias de la Salud Mexicali, Universidad Autónoma de Baja California, Mexicali 21000, BC, Mexico.ORCID 0000-0001-8543-5676
Octavio Galindo-HernándezFacultad de Medicina y Nutrición Mexicali, Universidad Autónoma de Baja California, Humberto Torres Sanginés S/N, Centro Cívico, Mexicali 21000, BC, Mexico.ORCID 0000-0003-4960-7551
José Luis Vique-SánchezCentro de Ciencias de la Salud Mexicali, Universidad Autónoma de Baja California, Mexicali 21000, BC, Mexico.
Raúl Díaz-MolinaFacultad de Medicina y Nutrición Mexicali, Universidad Autónoma de Baja California, Humberto Torres Sanginés S/N, Centro Cívico, Mexicali 21000, BC, Mexico.ORCID 0000-0002-9400-5683
Santiago VillafañaEscuela Superior de Medicina, Instituto Politécnico Nacional, Ciudad de México 11340, Mexico.ORCID 0000-0002-8660-7393
Victor García-GonzálezFacultad de Medicina y Nutrición Mexicali, Universidad Autónoma de Baja California, Humberto Torres Sanginés S/N, Centro Cívico, Mexicali 21000, BC, Mexico.ORCID 0000-0002-9421-3730

Funding

Coordinación General de Investigación y Posgrado/UABC 23a. Convocatoria Interna de Apoyo a Proyectos de InvestigaciónFondo Sectorial de Investigación para la Educación CB 2017-2018 A1-S-28653/SEP/CONACYTProgramas Nacionales Estratégicos de Ciencia, Tecnología y Vinculación con los Sectores Social, Público y Privado Programa Presupuestario F003
6 · The paper itself

Abstract

Tamoxifen remains the standard treatment for estrogen receptor alpha (ER α) positive breast cancer (BC) cases. However, a significant proportion of patients develop chemoresistance, leading to disease recurrence. The Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2), coded by

Indexed as

Breast NeoplasmsDrug Resistance, NeoplasmNF-E2-Related Factor 2RNA, Small InterferingCell Line, TumorCell MovementFemaleGene Expression Regulation, NeoplasticHumansMCF-7 CellsNeoplasm MetastasisTamoxifenNFE2L2 protein, humanNF-E2-Related Factor 2RNA, Small InterferingTamoxifenbreast cancerchemoresistancemetastasisNrf2tamoxifen

Identifiers

PMID42196483
PMCPMC13207780

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.