ReviewInternational journal of molecular sciences2026
Mechanisms Involved in Pathological Succinate-Mediated Signaling.
Review in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Transcriptional Regulation of Receptor-Mediated Mitophagy in Sunitinib-Resistant Renal Cancer Cells: Response to Succinic Acid.Pharmaceuticals (Basel, Switzerland) · 2026Article
- Microbial metabolic memory in inflammatory bowel disease: microbiota-derived metabolites, host-microbe reprogramming, and relapse susceptibility.Frontiers in microbiology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Succinate is a key intermediate of the Krebs cycle, which has increasing recognition for its roles beyond energy metabolism, including inflammation, cellular signaling, and metabolic regulation. Extracellular succinate, in particular, has been recognized as a signaling molecule that acts via the succinate receptor 1 (SUCNR1). SUCNR1-mediated signaling, however, demonstrates significant heterogeneity across various pathological contexts, resulting in varied and occasionally contradictory biological outcomes. This complexity underscores the context-dependent characteristics of succinate signaling and its significance in disease progression. This review will offer a comprehensive analysis of the signaling pathways activated during the interaction of succinate with its receptor in various tissues, as well as the potential of succinate regulation to ameliorate several pathological conditions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.