Evidence map›Paper›PMID 42196296›Full record

ArticleInternational journal of molecular sciences2026

The Role and Mechanism of Nrf2 in Ameliorating Oxidative Stress and Inflammation in IR Mice by Aerobic Exercise.

Xuan Liu, Yuqing Ding, Tao Chen, Zhengkang Wu, Shujuan Hu, Xianwang Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xuan LiuSchool of Education and Physical Education, Yangtze University, Jingzhou 434023, China.
Yuqing DingSchool of Education and Physical Education, Yangtze University, Jingzhou 434023, China.
Tao ChenSchool of Education and Physical Education, Yangtze University, Jingzhou 434023, China.ORCID 0009-0009-6129-1343
Zhengkang WuSchool of Education and Physical Education, Yangtze University, Jingzhou 434023, China.
Shujuan HuSchool of Education and Physical Education, Yangtze University, Jingzhou 434023, China.
Xianwang WangDepartment of Biochemistry and Molecular Biology, Center for Molecular Medicine, Yangtze University, Jingzhou 434023, China.

Funding

Hubei Province Key R & D Program Aid Project to Tibet, Shannan Science and Technology Plan Project SNSBJKJJHXM2024023Hubei Provincial Department of Education 25Y117Science and Technology Department of Hubei Province 2025AFB925Tibet Autonomous Region Science and Technology Agency XZ202501ZR0140Yangtze University 2025csz005Yangtze University JY2024066Yangtze University Yz2024179
6 · The paper itself

Abstract

This study explored the regulatory role of nuclear factor E2-related factor 2 (Nrf2) in aerobic exercise improving oxidative stress and inflammatory responses in mice with insulin resistance (IR) induced by a high-fat diet. We established an IR mouse model through a high-fat diet, then subjected the IR mice to aerobic exercise, intraperitoneal injection of luteolin, or a combined intervention. After 6 weeks of intervention, we measured serum lipid and glucose profiles; evaluated skeletal muscle morphology by H&E staining; quantified mRNA expression levels of Nrf2 and its downstream targets in the skeletal muscle by RT-qPCR; and determined protein abundance, localization, and expression patterns of Nrf2 and NOD-like receptor protein 3 (NLRP3) inflammasome by Western blotting and immunohistochemistry, respectively. In the skeletal muscle of IR mice, Nrf2 and its downstream targets were significantly down-regulated, whereas NLRP3 inflammasome was markedly up-regulated (

Indexed as

InflammationInsulin ResistanceNF-E2-Related Factor 2Oxidative StressPhysical Conditioning, AnimalAnimalsBlood GlucoseDiet, High-FatInflammasomesMaleMiceMice, Inbred C57BLMuscle, SkeletalNLR Family, Pyrin Domain-Containing 3 ProteinBlood GlucoseInflammasomesNfe2l2 protein, mouseNF-E2-Related Factor 2NLR Family, Pyrin Domain-Containing 3 Proteinaerobic exerciseinflammationinsulin resistanceNrf2oxidative stress

Identifiers

PMID42196296
PMCPMC13208033

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.