Evidence map›Paper›PMID 42196285›Full record

ArticleInternational journal of molecular sciences2026

A Transgenic Mouse Model to Track MRC1-High Macrophages Using In Vivo Optical Imaging.

Chintan Chawda, Giorgia Zambito, Natasa Gaspar, Christopher Schliehe, Pieter J M Leenen, Clemens Löwik, Laura Mezzanotte

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Chintan ChawdaDepartment of Radiology and Nuclear Medicine, Erasmus MC Cancer Institute, Erasmus University Medical Center Rotterdam, Molenwaterplein 40, 3015 GD Rotterdam, The Netherlands.
Giorgia ZambitoDepartment of Radiology and Nuclear Medicine, Erasmus MC Cancer Institute, Erasmus University Medical Center Rotterdam, Molenwaterplein 40, 3015 GD Rotterdam, The Netherlands.
Natasa GasparDepartment of Radiology and Nuclear Medicine, Erasmus MC Cancer Institute, Erasmus University Medical Center Rotterdam, Molenwaterplein 40, 3015 GD Rotterdam, The Netherlands.
Christopher SchlieheDepartment of Immunology, Erasmus MC Cancer Institute, Erasmus University Medical Center Rotterdam, 3015 CN Rotterdam, The Netherlands.ORCID 0000-0002-1923-8620
Pieter J M LeenenDepartment of Immunology, Erasmus MC Cancer Institute, Erasmus University Medical Center Rotterdam, 3015 CN Rotterdam, The Netherlands.ORCID 0000-0001-9860-2920
Clemens LöwikDepartment of Radiology and Nuclear Medicine, Erasmus MC Cancer Institute, Erasmus University Medical Center Rotterdam, Molenwaterplein 40, 3015 GD Rotterdam, The Netherlands.
Laura MezzanotteDepartment of Radiology and Nuclear Medicine, Erasmus MC Cancer Institute, Erasmus University Medical Center Rotterdam, Molenwaterplein 40, 3015 GD Rotterdam, The Netherlands.ORCID 0000-0001-5592-8904

Funding

EU-MSCA-ITN-PAVE 861190National Institute of Health Usa R21 grant CA274064
6 · The paper itself

Abstract

Macrophages play a crucial role in health and disease. Currently, reporter mice for tracking alternatively activated macrophages in vivo are lacking. We designed a transgenic mouse model in which luminescence and fluorescence proteins, click beetle red luciferase (CBRED2) and mKate2, report on the expression of the Mrc1/Cd206 promoter, active in the monocyte/macrophage population. The mouse line was named B6Mrc1-

Indexed as

Carcinoma, Pancreatic DuctalMacrophagesOptical ImagingPancreatic NeoplasmsReceptors, Cell SurfaceAnimalsDisease Models, AnimalGenes, ReporterLectins, C-TypeMannose-Binding LectinsMannose ReceptorMiceMice, TransgenicPromoter Regions, GeneticTumor MicroenvironmentLectins, C-TypeMannose-Binding LectinsMannose ReceptorReceptors, Cell SurfaceCD206macrophagesmannose receptor C-type 1optical in vivo imagingpancreatic ductal adenocarcinomatransgenic reporter mice

Identifiers

PMID42196285
PMCPMC13207300

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.