Evidence map›Paper›PMID 42196273›Full record

ArticleInternational journal of molecular sciences2026

Iodine-Based Coordination Compounds: A Strategy Toward Antibiotic Potentiation.

Daniil Shepilov, Dana Askarova, Anar Seisembekova, Seitzhan Turganbay, Ardak Jumagaziyeva, Tamara Bukeyeva, Gulnara Yuldasheva, Nurdaulet Temir, Lyudmila N Ivanova, Natalya Zubenko and 1 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Daniil ShepilovJSC Scientific Center for Anti-Infectious Drugs, Almaty 050060, Kazakhstan.ORCID 0009-0003-0471-0587
Dana AskarovaJSC Scientific Center for Anti-Infectious Drugs, Almaty 050060, Kazakhstan.
Anar SeisembekovaJSC Scientific Center for Anti-Infectious Drugs, Almaty 050060, Kazakhstan.ORCID 0000-0002-7791-3145
Seitzhan TurganbayFaculty of Natural Sciences, Kazakh National Women's Teacher Training University, Almaty 050000, Kazakhstan.ORCID 0000-0001-9621-3534
Ardak JumagaziyevaJSC Scientific Center for Anti-Infectious Drugs, Almaty 050060, Kazakhstan.ORCID 0000-0002-8610-7321
Tamara BukeyevaJSC Scientific Center for Anti-Infectious Drugs, Almaty 050060, Kazakhstan.ORCID 0000-0002-3100-6523
Gulnara YuldashevaJSC Scientific Center for Anti-Infectious Drugs, Almaty 050060, Kazakhstan.ORCID 0000-0003-2881-0307
Nurdaulet TemirJSC Scientific Center for Anti-Infectious Drugs, Almaty 050060, Kazakhstan.ORCID 0009-0008-8533-3029
Lyudmila N IvanovaJSC Scientific Center for Anti-Infectious Drugs, Almaty 050060, Kazakhstan.ORCID 0000-0002-7194-0556
Natalya ZubenkoJSC Scientific Center for Anti-Infectious Drugs, Almaty 050060, Kazakhstan.ORCID 0000-0001-6436-803X
Sabina KeneshevaJSC Scientific Center for Anti-Infectious Drugs, Almaty 050060, Kazakhstan.ORCID 0000-0001-9154-1424

Funding

Committee of Science of the Ministry of Science and Higher Education BR24992760
6 · The paper itself

Abstract

Due to the increasing threat of antibiotic resistance and the emergence of new pathogenic strains, the development of effective combined therapeutic agents represents a crucial direction in the fight against infections. Within this study, several compounds were synthesized in which iodine is present in a coordination complex with antibiotics-sodium sulfadimidine and gentamicin sulfate. The physicochemical parameters of these compounds were investigated using capillary electrophoresis and UV spectroscopy, along with their cytotoxicity, antimicrobial, and antiviral activities. As a result of this work, two stable compounds, KC-246 and KC-248, were synthesized, demonstrating virus-inhibitory activity against herpes simplex virus and influenza A under extremely low cytotoxicity levels of 0.018-0.106 mg/mL. Additionally, they exhibited antimicrobial activity against representatives of the families

Indexed as

Anti-Bacterial AgentsAntiviral AgentsCoordination ComplexesIodineHumansMicrobial Sensitivity TestsAnti-Bacterial AgentsAntiviral AgentsCoordination ComplexesIodineactive pharmaceutical substancesdrug–drug synergyiodine-containing compoundsnovel antimicrobial adjuvantsresistance mitigation

Identifiers

PMID42196273
PMCPMC13207560

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.