Evidence map›Paper›PMID 42196272›Full record

ArticleInternational journal of molecular sciences2026

Type-1 Ryanodine Receptor Plays an Important Role in Cardiac Hypertrophy and Heart Failure by Increasing Type-2 Ryanodine Receptor-Mediated Calcium Release.

Yong-Xiao Wang, Ed Wilson Santos, Sarahann Mistretta, Yuexing Yuan, Harold A Singer, Shey-Shing Sheu, Yun-Min Zheng

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yong-Xiao WangDepartment of Molecular and Cellular Physiology, Albany Medical College, Albany, NY 12208, USA.ORCID 0000-0002-2674-7116
Ed Wilson SantosDepartment of Molecular and Cellular Physiology, Albany Medical College, Albany, NY 12208, USA.ORCID 0000-0002-7736-9645
Sarahann MistrettaDepartment of Molecular and Cellular Physiology, Albany Medical College, Albany, NY 12208, USA.
Yuexing YuanCenter for Translational Medicine, Department of Medicine, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Harold A SingerDepartment of Molecular and Cellular Physiology, Albany Medical College, Albany, NY 12208, USA.
Shey-Shing SheuCenter for Translational Medicine, Department of Medicine, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA.ORCID 0000-0003-3838-3601
Yun-Min ZhengDepartment of Molecular and Cellular Physiology, Albany Medical College, Albany, NY 12208, USA.

Funding

Novel signaling in chronic hypoxic responses in pulmonary arteriesR01HL122865 · NHLBI · ALBANY MEDICAL COLLEGE · PI WANG, YONG-XIAO · 2015 to 2018
$1.9M
Cerebral vascular calcium signaling in diabetic Alzheimer's disease-related dementiasR03AG070784 · NIA · ALBANY MEDICAL COLLEGE · PI WANG, YONG-XIAO · 2021 to 2021
$326k
International Heart and Lung Institute R01HL108232NHLBI NIH HHS R01HL122865NIA NIH HHS R03AG070784
6 · The paper itself

Abstract

Type-1 ryanodine receptor (RyR1) is essential for skeletal muscle contraction. This Ca

Indexed as

CalciumCardiomegalyHeart FailureRyanodine Receptor Calcium Release ChannelAnimalsDogsHumansMaleMiceMyocytes, CardiacCalciumryanodine receptor 1, mouseryanodine receptor 2. mouseRyanodine Receptor Calcium Release ChannelCa2+ releasecardiac hypertrophyheart failureRyR1RyR2

Identifiers

PMID42196272
PMCPMC13207715

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.