Pla2g6 Deficiency Induces Neuronal Precursor Apoptosis During Neurodevelopment.

Yang-Jin Shen, Han-Fang Liu, Ting-Chen Hsu, Yi-Chieh Chen, Yi-Chuan Cheng

Abstract read

In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Yang-Jin ShenGraduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan 333323, Taiwan.ORCID 0009-0000-0032-5284

Han-Fang LiuGraduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan 333323, Taiwan.ORCID 0000-0002-1816-2556

Ting-Chen HsuGraduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan 333323, Taiwan.

Yi-Chieh ChenNeuroscience Research Center, Chang Gung Memorial Hospital, Linkou, Taoyuan 333423, Taiwan.ORCID 0000-0002-6054-8321

Yi-Chuan ChengGraduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan 333323, Taiwan.ORCID 0000-0002-4772-2380

Funding

Chang Gung Memorial Hospital CMRPD1P0041, CMRPD1P0042, and BMRP857National Science and Technology Council NSTC 113-2320-B-182 -029 -MY3

6 · The paper itself

Abstract

Phospholipase A2 group VI (PLA2G6) regulates phospholipid remodeling and cellular homeostasis, and its mutations cause neurodegenerative disorders, including neurodegeneration with brain iron accumulation and PLA2G6-associated parkinsonism (PARK14). Although many cases present in adulthood, a substantial subset shows early onset, indicating that PLA2G6 dysfunction can affect neuronal systems during developmental stages. However, whether PLA2G6 directly regulates early neurogenesis remains undefined. Here, using zebrafish embryos, we investigated the role of Pla2g6 during neural development through loss- and gain-of-function approaches.

Indexed as

ApoptosisGroup VI Phospholipases A2Neural Stem CellsNeurogenesisZebrafish ProteinsAnimalsGene Expression Regulation, DevelopmentalNeurodevelopmentNeuronsOxidative StressReactive Oxygen SpeciesZebrafishGroup VI Phospholipases A2Reactive Oxygen SpeciesZebrafish Proteinsapoptosisneurogenesisneuronal precursorsoxidative stressparkinsonismPla2g6

Identifiers

PMID42196263

DOI10.3390/ijms27104280

PMCPMC13207329

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.