Evidence map›Paper›PMID 42196247›Full record

ReviewInternational journal of molecular sciences2026

Polymorphism in the TLR Adaptors of the Toll Signalling Pathway for Use in Livestock Breeding for Health Traits.

Karel Novák, Kalifa Samaké

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Karel NovákDepartment of Genetics and Breeding of Farm Animals, Institute of Animal Science, Přátelství 815, Uhříněves, 104 00 Prague, Czech Republic.ORCID 0000-0002-9366-3764
Kalifa SamakéDepartment of Genetics and Microbiology, Charles University, Viničná 7, 128 43 Prague, Czech Republic.ORCID 0009-0008-0972-6373

Funding

Ministry of Agriculture of the Czech Republic, in frame of the long-term development project for the Institute of Animal Science in Prague project No. RO0723, for the years 2023 - 2027
6 · The paper itself

Abstract

Infections in animal production industries can be reduced through targeted breeding of animals with genetically enhanced disease resistance. This type of breeding should be based on a thorough understanding of host defence and its underlying mechanisms. The genes controlling the components of the innate immune system represent a primary target. Their function is highly sensitive to any mutational changes in their structure, which has been optimised through long-term evolution. A source of variability is provided by the polymorphism in the genes encoding components of the Toll signalling pathway as one of the main subsystems of innate immunity. The associated set of genes comprises the group of

Indexed as

BreedingLivestockPolymorphism, GeneticSignal TransductionToll-Like ReceptorsAnimalsHumansImmunity, InnateMyeloid Differentiation Factor 88Myeloid Differentiation Factor 88Toll-Like Receptorsbioinformaticscattlefunctional predictiongenotypinghealth traitsimmunogeneticsNGSSNP

Identifiers

PMID42196247
PMCPMC13207514

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.