ArticleInternational journal of molecular sciences2026
Salidroside Protects Against Simazine-Induced Neurotoxicity by Activating
Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Simazine (SIM), a triazine herbicide and potential environmental risk factor, has been associated with neurotoxicity; however, the underlying mechanisms remain poorly characterized. Salidroside (SAL), a natural antioxidant with mitochondrial protective properties, has been reported to alleviate SIM-induced neuronal injury. Using an integrated strategy combining network toxicology and network pharmacology with experimental validation, this study systematically investigated the neurotoxic mechanisms of SIM and the neuroprotective effects of SAL. Bioinformatics analyses revealed that SIM- and SAL-related targets were significantly enriched in apoptosis- and autophagy-associated pathways. In vitro experiments demonstrated that SIM induced mitochondrial structural damage, metabolic dysfunction, and dopaminergic neuron-like SH-SY5Y cells apoptosis by inhibiting
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