ATF3 Modulates the Endoplasmic Reticulum Stress-Induced Impairment of Milk Synthesis in Bovine Mammary Epithelial Cells.

Chen Zhang, Wenting Dai, Yue Liu, Hongwei Xu, Hongyun Liu

Abstract read

In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Chen ZhangCollege of Animal Sciences, Zhejiang University, Hangzhou 310058, China.

Wenting DaiCollege of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, China.

Yue LiuCollege of Animal Sciences, Zhejiang University, Hangzhou 310058, China.

Hongwei XuSchool of Bioengineering, Northwest Minzu University, Lanzhou 730030, China.

Hongyun LiuCollege of Animal Sciences, Zhejiang University, Hangzhou 310058, China.ORCID 0000-0001-8806-6204

Funding

China Agriculture Research System CARS-36National Natural Science Foundation of China 32573231

6 · The paper itself

Abstract

Due to the substantial secretory burden, bovine mammary epithelial cells (BMECs) are highly susceptible to endoplasmic reticulum (ER) stress caused by the accumulation of misfolded proteins when protein-folding capacity is overwhelmed. However, how ATF3 regulates ER stress-induced impairment of milk synthesis and apoptosis in BMECs, particularly through its direct transcriptional targets, remains poorly understood. In this study, we investigated the protective role of activating transcription factor 3 (ATF3) against ER stress-induced impairment of milk synthesis in BMECs. Using a tunicamycin-induced ER stress model, we overexpressed

Indexed as

Activating Transcription Factor 3Endoplasmic Reticulum StressEpithelial CellsMammary Glands, AnimalMilkAnimalsApoptosisCattleFemaleGene Expression RegulationLactationSignal TransductionActivating Transcription Factor 3activating transcription factor 3apoptosisbovine mammary epithelial cellsendoplasmic reticulum stressmilk synthesis

Identifiers

PMID42196231

DOI10.3390/ijms27104250

PMCPMC13206812

What OpenQuestion holds

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LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.