Evidence map›Paper›PMID 42196228›Full record

ArticleInternational journal of molecular sciences2026

Preliminary IL-1 Family Cytokine Signature for Crohn's Disease Onset in Pediatric Juvenile Idiopathic Arthritis.

Angelina V Polyanskaya, Anna G Soboleva, Alexandre Mezentsev, Vladimir V Sobolev, Svetlana N Chebysheva, Natalia A Geppe, Elena S Zholobova, Maria K Osminina, Vera A Podzolkova, Marina D Shakhnazarova and 3 more

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Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Angelina V PolyanskayaSechenov First Moscow State Medical University (Sechenov University), 8 Trubetskaya Street, Building 2, Moscow 119048, Russia.
Anna G SobolevaAvtsyn Research Institute of Human Morphology, Federal State Budgetary Scientific Institution "Petrovsky National Research Centre of Surgery", Moscow 119991, Russia.ORCID 0000-0002-9158-1933
Alexandre MezentsevCenter for Theoretical Problems of Physicochemical Pharmacology, Russian Academy of Sciences, Moscow 119334, Russia.ORCID 0000-0002-4972-9922
Vladimir V SobolevCenter for Theoretical Problems of Physicochemical Pharmacology, Russian Academy of Sciences, Moscow 119334, Russia.ORCID 0000-0003-4779-156X
Svetlana N ChebyshevaSechenov First Moscow State Medical University (Sechenov University), 8 Trubetskaya Street, Building 2, Moscow 119048, Russia.
Natalia A GeppeSechenov First Moscow State Medical University (Sechenov University), 8 Trubetskaya Street, Building 2, Moscow 119048, Russia.
Elena S ZholobovaSechenov First Moscow State Medical University (Sechenov University), 8 Trubetskaya Street, Building 2, Moscow 119048, Russia.
Maria K OsmininaSechenov First Moscow State Medical University (Sechenov University), 8 Trubetskaya Street, Building 2, Moscow 119048, Russia.
Vera A PodzolkovaSechenov First Moscow State Medical University (Sechenov University), 8 Trubetskaya Street, Building 2, Moscow 119048, Russia.ORCID 0000-0002-0701-5956
Marina D ShakhnazarovaSechenov First Moscow State Medical University (Sechenov University), 8 Trubetskaya Street, Building 2, Moscow 119048, Russia.ORCID 0000-0003-3512-5455
Olga G Suhov'evaSechenov First Moscow State Medical University (Sechenov University), 8 Trubetskaya Street, Building 2, Moscow 119048, Russia.
Irina M FarberSechenov First Moscow State Medical University (Sechenov University), 8 Trubetskaya Street, Building 2, Moscow 119048, Russia.
Irina M KorsunskayaCenter for Theoretical Problems of Physicochemical Pharmacology, Russian Academy of Sciences, Moscow 119334, Russia.ORCID 0000-0002-6583-0318

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Crohn's disease (CD) in children with juvenile idiopathic arthritis (JIA) is frequently diagnosed late due to overlapping symptoms and non-specific biomarkers. We hypothesized that longitudinal cytokine profiling could identify a pre-symptomatic signature predictive of CD conversion in pediatric JIA patients. Ninety pediatric participants (JIA, CD, psoriatic arthritis, healthy controls) underwent serum cytokine profiling (IL-1α, IL-1β, IL-36α, IL-37, IL-6, IL-18, IL-27, IL-31) at baseline and 12 months. Statistical analysis used Mann-Whitney U tests for two-group comparisons, the Kruskal-Wallis test with Dunn's post hoc for multi-group comparisons, Fisher's Exact Test for categorical outcomes, and exploratory principal component analysis (PCA). Baseline screening identified a subgroup of JIA patients (

Indexed as

Arthritis, JuvenileCrohn DiseaseCytokinesInterleukin-1AdolescentBiomarkersChildChild, PreschoolFemaleHumansMaleBiomarkersCytokinesInterleukin-1biomarker discoveryCrohn’s diseasecytokine profilingIL-1 familyjuvenile idiopathic arthritispediatric inflammatory bowel diseasepsoriatic arthritistranslational immunology

Identifiers

PMID42196228
PMCPMC13208062

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.