Evidence map›Paper›PMID 42196191›Full record

ArticleInternational journal of molecular sciences2026

Longitudinal CSF and Serum Biomarker Dynamics in Tofersen-Treated

Andrea Giordano, Jessica Mandrioli, Federica Cerri, Christian Lunetta, Hamidreza Saebfar, Marcella Catania, Claudia Battipaglia, Laura Leone, Francesca Trojsi, Maria Vizziello and 13 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Andrea GiordanoNeurology 3-Neuroalgology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Via Celoria 11, 20133 Milan, Italy.ORCID 0000-0002-3676-7911
Jessica MandrioliDepartment of Neurosciences, Ospedale Civile Baggiovara, Azienda Ospedaliero Universitaria di Modena, Via Giardini 1355, 41126 Modena, Italy.ORCID 0000-0002-9244-9782
Federica CerriNEuroMuscular Omnicentre, Fondazione Serena ETS, Piazza dell'Ospedale Maggiore, 3, 20162 Milan, Italy.ORCID 0009-0003-1619-2019
Christian LunettaNeurorehabilitation Department, Istituti Clinici Scientifici Maugeri IRCCS, Via Camaldoli 64, 20138 Milan, Italy.
Hamidreza SaebfarNeurology 3-Neuroalgology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Via Celoria 11, 20133 Milan, Italy.
Marcella CataniaNeurology 8-Dementias and Degenerative Diseases of Central Nervous System Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Via Celoria 11, 20133 Milan, Italy.ORCID 0000-0003-0370-1905
Claudia BattipagliaNeurology 8-Dementias and Degenerative Diseases of Central Nervous System Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Via Celoria 11, 20133 Milan, Italy.
Laura LeoneNeurology 3-Neuroalgology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Via Celoria 11, 20133 Milan, Italy.
Francesca TrojsiNeurology Unit, First Division of Neurology and Neurophysiopathology, AOU University of Campania "Luigi Vanvitelli", Piazza Miraglia 2, 80138 Naples, Italy.ORCID 0000-0002-3790-8018
Maria VizzielloNeurology 3-Neuroalgology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Via Celoria 11, 20133 Milan, Italy.ORCID 0000-0002-7005-689X
Francesca GerardiNEuroMuscular Omnicentre, Fondazione Serena ETS, Piazza dell'Ospedale Maggiore, 3, 20162 Milan, Italy.
Matteo FarèNEuroMuscular Omnicentre, Fondazione Serena ETS, Piazza dell'Ospedale Maggiore, 3, 20162 Milan, Italy.ORCID 0000-0001-8956-7406
Aida ZuluetaNeurorehabilitation Department, Istituti Clinici Scientifici Maugeri IRCCS, Via Camaldoli 64, 20138 Milan, Italy.ORCID 0000-0001-8295-6847
Rachele PirasNeurorehabilitation Department, Istituti Clinici Scientifici Maugeri IRCCS, Via Camaldoli 64, 20138 Milan, Italy.ORCID 0009-0000-8095-1014
Matteo GiacchinoDepartment of Neurosciences, Ospedale Civile Baggiovara, Azienda Ospedaliero Universitaria di Modena, Via Giardini 1355, 41126 Modena, Italy.
Giulia GianferrariDepartment of Neurosciences, Ospedale Civile Baggiovara, Azienda Ospedaliero Universitaria di Modena, Via Giardini 1355, 41126 Modena, Italy.ORCID 0000-0002-4260-0915
Eleonora Dalla BellaNeurology 3-Neuroalgology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Via Celoria 11, 20133 Milan, Italy.
Teuta DomiDivision of Neuroscience, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, 20132 Milan, Italy.
Dario BonanomiDivision of Neuroscience, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, 20132 Milan, Italy.
Giuseppe GanciNeurointerventional Radiology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Via Celoria 11, 20133 Milan, Italy.
Raffaella LombardiNeurology 3-Neuroalgology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Via Celoria 11, 20133 Milan, Italy.
Giuseppe LauriaNeurology 3-Neuroalgology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Via Celoria 11, 20133 Milan, Italy.
Nilo RivaNeurology 3-Neuroalgology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Via Celoria 11, 20133 Milan, Italy.ORCID 0000-0002-0513-9517

Funding

AriSLA IDEALSFondazione Cassa di Risparmio di Modena Neurobiobanca di ModenaGiovanni Marazzina Foundation Giovanni Marazzina ProjectMinistero della salute Ricerca Finalizzata bando 2021 RF-2021-12373036
6 · The paper itself

Abstract

Tofersen is a gene-targeted therapy for superoxide dismutase 1 (

Indexed as

Amyotrophic Lateral SclerosisBiomarkersSuperoxide Dismutase-1AgedFemaleGlial Fibrillary Acidic ProteinHumansLongitudinal StudiesMaleMiddle AgedNeurofilament ProteinsRetrospective Studiestau ProteinsUbiquitin ThiolesteraseBiomarkersGlial Fibrillary Acidic Proteinneurofilament protein LNeurofilament ProteinsSOD1 protein, humanSuperoxide Dismutase-1tau ProteinsUbiquitin ThiolesteraseUCHL1 protein, humancerebrospinal fluidGFAPlongitudinal studyneurofilament light chainprecision medicineserum biomarkersSOD1-ALStofersentotal TauUCHL–1

Identifiers

PMID42196191
PMCPMC13207959

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.