Evidence map›Paper›PMID 42196186›Full record

ReviewInternational journal of molecular sciences2026

Inflammatory Memory of Adipose Tissue Macrophages: From CD68 Footprint to Cardiometabolic and Cancer Risk During Weight Cycling.

Dragana Tomić Naglić, Mia Manojlović, Slađana Pejaković, Nikolina Vuković, Teodor Grbić, Ognjen Milanović, Milan Mirković, Slobodan Maričić, Tamara Maksimović, Andrijana Milankov

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Dragana Tomić NaglićFaculty of Medicine, University of Novi Sad, 21137 Novi Sad, Serbia.
Mia ManojlovićFaculty of Medicine, University of Novi Sad, 21137 Novi Sad, Serbia.
Slađana PejakovićRegena Polyclinic, 21101 Novi Sad, Serbia.ORCID 0000-0002-9654-6395
Nikolina VukovićFaculty of Medicine, University of Novi Sad, 21137 Novi Sad, Serbia.ORCID 0009-0001-8892-4325
Teodor GrbićClinic for Endocrinology, Diabetes and Metabolic Disorders, University Clinical Center of Vojvodina, 21000 Novi Sad, Serbia.
Ognjen MilanovićFaculty of Medicine, University of Novi Sad, 21137 Novi Sad, Serbia.ORCID 0009-0006-6566-9882
Milan MirkovićFaculty of Medicine, University of Novi Sad, 21137 Novi Sad, Serbia.ORCID 0009-0007-0915-8938
Slobodan MaričićFaculty of Medicine, University of Novi Sad, 21137 Novi Sad, Serbia.ORCID 0000-0001-6278-7476
Tamara MaksimovićFaculty of Medicine, University of Novi Sad, 21137 Novi Sad, Serbia.ORCID 0000-0002-9761-736X
Andrijana MilankovFaculty of Medicine, University of Novi Sad, 21137 Novi Sad, Serbia.ORCID 0000-0001-5815-3892

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Obesity is characterized by chronic low-grade inflammation (meta-inflammation) and metabolic dysregulation. Adipose tissue acts as an immunometabolic organ, with macrophages playing a central role. This review examines inflammatory memory in adipose tissue, focusing on CD68+ macrophages and their role in cardiometabolic and cancer risk during weight cycling. (2) Narrative synthesis of evidence from immunology, obesitology, and oncology, with emphasis on macrophage polarization and signaling pathways. (3) Weight cycling induces persistent immune memory in adipose tissue, characterized by exaggerated macrophage responses upon weight regain. CD68+ macrophages contribute to extracellular matrix remodeling, tumor signaling, and metabolic dysfunction. Key mechanisms include PI3K/AKT/mTOR dysregulation, FOXO1/KLF10 axis impairment, and CREB-mediated transcription. This inflammatory memory promotes atherosclerosis progression, insulin resistance, and increased cancer risk, despite prior weight loss. (4) Macrophage-driven inflammatory memory represents a key mechanistic link between obesity, cardiometabolic disease, and cancer. Targeting meta-inflammation independent of body weight should be integral to future therapies.

Indexed as

Adipose TissueAntigens, CDAntigens, Differentiation, MyelomonocyticCardiovascular DiseasesInflammationMacrophagesNeoplasmsObesityAnimalsCD68 MoleculeHumansSignal TransductionAntigens, CDAntigens, Differentiation, MyelomonocyticCD68 antigen, humanCD68 Moleculeadipose tissuecancer progressioncardiometabolic riskCD68macrophagesmeta-inflammationobesityPI3K/AKT/mTORweight cycling

Identifiers

PMID42196186
PMCPMC13207334

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.