Evidence map›Paper›PMID 42196182›Full record

ArticleInternational journal of molecular sciences2026

Single-Cell Proteomics Decodes the Cellular Response to Lysosomal Storage in

Yiming Lei, Fanghua Lu, Qinqin Xu, Lishuan Wu, Qun Fang, Hongyun Tang

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yiming LeiSchool of Life Sciences, Fudan University, Shanghai 200433, China.
Fanghua LuSingle-Cell Proteomics Research Center, and Zhejiang Key Laboratory of Intelligent Manufacturing for Functional Chemicals, ZJU-Hangzhou Global Scientific and Technological Innovation Center, Zhejiang University, Hangzhou 311200, China.
Qinqin XuDepartment of Chemistry, Zhejiang University, Hangzhou 310058, China.
Lishuan WuState Key Laboratory of Gene Expression, School of Life Sciences, Westlake University, Hangzhou 310030, China.
Qun FangSingle-Cell Proteomics Research Center, and Zhejiang Key Laboratory of Intelligent Manufacturing for Functional Chemicals, ZJU-Hangzhou Global Scientific and Technological Innovation Center, Zhejiang University, Hangzhou 311200, China.
Hongyun TangSchool of Life Sciences, Fudan University, Shanghai 200433, China.

Funding

National Natural Science Foundation of China 22527805National Natural Science Foundation of China 32070565National Natural Science Foundation of China 32350015National Natural Science Foundation of China 32530030Zhejiang Provincial Natural Science Foundation 2024C03144Zhejiang Provincial Natural Science Foundation LQ23C040002Zhejiang Provincial Natural Science Foundation QN25C070004Zhejiang Provincial Natural Science Foundation XHD24C0701
6 · The paper itself

Abstract

Lysosomal storage, characterized by the progressive accumulation of undigested substrates in the lysosomal lumen, is a primary driver of various lysosome-related diseases. However, single-cell proteomic remodeling during lysosomal storage remains elusive, and the cellular responses for coping with this condition are poorly understood. Here, we employed deep-coverage single-cell proteomics to analyze

Indexed as

Caenorhabditis elegansCaenorhabditis elegans ProteinsLysosomesProteomeProteomicsSingle-Cell AnalysisAnimalsEndoplasmic ReticulumMitochondriaProteasome Endopeptidase ComplexProteostasisProteotoxic StressUnfolded Protein ResponseCaenorhabditis elegans ProteinsProteasome Endopeptidase ComplexProteomeCaenorhabditis eleganscellular stress responselysosomal storageproteostasissingle-cell proteomics

Identifiers

PMID42196182
PMCPMC13207671

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.