Evidence map›Paper›PMID 42196155›Full record

ArticleInternational journal of molecular sciences2026

Effect of PI3K-p110α Inhibitor Alpelisib in the Differentiation and Effector Functions of M-CSF and GM-CSF Macrophages.

Cristina Villa-Gómez, Verónica Bermejo, Inmaculada Márquez-Leiva, Jana Baranda, Alejandro C Briones, Isabel Cervera, Jordi Ochando, José María Rojo, Pilar Portolés

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Cristina Villa-GómezImmunology Department, National Centre for Microbiology (CNM), Carlos III Health Institute (ISCIII), 28220 Madrid, Spain.ORCID 0000-0002-7520-1603
Verónica BermejoImmunology Department, National Centre for Microbiology (CNM), Carlos III Health Institute (ISCIII), 28220 Madrid, Spain.
Inmaculada Márquez-LeivaImmunology Department, National Centre for Microbiology (CNM), Carlos III Health Institute (ISCIII), 28220 Madrid, Spain.
Jana BarandaImmunology Department, National Centre for Microbiology (CNM), Carlos III Health Institute (ISCIII), 28220 Madrid, Spain.ORCID 0000-0002-9060-9228
Alejandro C BrionesImmunology Department, National Centre for Microbiology (CNM), Carlos III Health Institute (ISCIII), 28220 Madrid, Spain.ORCID 0000-0003-4016-1848
Isabel CerveraImmunology Department, National Centre for Microbiology (CNM), Carlos III Health Institute (ISCIII), 28220 Madrid, Spain.
Jordi OchandoImmunology Department, National Centre for Microbiology (CNM), Carlos III Health Institute (ISCIII), 28220 Madrid, Spain.
José María RojoMargarita Salas Center for Biological Research (CIB), Spanish National Research Council (CSIC), 28040 Madrid, Spain.ORCID 0000-0001-9032-0072
Pilar PortolésImmunology Department, National Centre for Microbiology (CNM), Carlos III Health Institute (ISCIII), 28220 Madrid, Spain.ORCID 0000-0001-6973-0835

Funding

Accion Estratégica en Salud Intramural (AESI) del Instituto de Salud Carlos III AESI PI21CIII/00022Accion Estratégica en Salud Intramural (AESI) del Instituto de Salud Carlos III PI23CIII/00057
6 · The paper itself

Abstract

Phosphatidylinositol-3-kinases (PI3Ks) are heterodimers of catalytic and regulatory subunits that regulate cell metabolism, activation, and survival. PI3K, particularly the p110α catalytic isoform, is frequently mutated in cancer, and highly specific inhibitors such as alpelisib are currently used in oncology and in

Indexed as

Cell DifferentiationClass I Phosphatidylinositol 3-KinasesGranulocyte-Macrophage Colony-Stimulating FactorMacrophage Colony-Stimulating FactorMacrophagesPhosphoinositide-3 Kinase InhibitorsAnimalsCytokinesMiceMonocytesNitric Oxide Synthase Type IIPhosphatidylinositol 3-KinasesSignal TransductionThiazolesAlpelisibClass I Phosphatidylinositol 3-KinasesCytokinesGranulocyte-Macrophage Colony-Stimulating FactorMacrophage Colony-Stimulating FactorNitric Oxide Synthase Type IIPhosphatidylinositol 3-KinasesPhosphoinositide-3 Kinase InhibitorsThiazolesalpelisib (BYL719)class I PI3-kinasesGM-CSFmacrophageM-CSFmonocytephosphatidylinositol-3-kinasesPI3K-p110αT lymphocyte

Identifiers

PMID42196155
PMCPMC13207794

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.